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10.1007/s10072-020-04541-z

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32643133!7342552!32643133
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suck abstract from ncbi


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pmid32643133      Neurol+Sci 2020 ; 41 (9): 2317-2324
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  • Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study #MMPMID32643133
  • Hwang JM; Kim JH; Park JS; Chang MC; Park D
  • Neurol Sci 2020[Sep]; 41 (9): 2317-2324 PMID32643133show ga
  • INTRODUCTION: In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death. METHODS: In this retrospective cohort study, we included 103 adult inpatients (aged >/= 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients. RESULTS: In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age. CONCLUSIONS: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.
  • |*Betacoronavirus[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*diagnosis/*mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung Diseases/diagnosis/mortality[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality/trends[MESH]
  • |Nervous System Diseases/*diagnosis/*mortality[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/*mortality[MESH]
  • |Predictive Value of Tests[MESH]
  • |Republic of Korea/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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