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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Mol+Cell+Biol 2020 ; 12 (12): 946-957 Nephropedia Template TP
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Proteome-wide data analysis reveals tissue-specific network associated with SARS-CoV-2 infection #MMPMID32642770
Feng L; Yin YY; Liu CH; Xu KR; Li QR; Wu JR; Zeng R
J Mol Cell Biol 2020[Jun]; 12 (12): 946-957 PMID32642770show ga
For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the damages to multiple organs have been clinically observed. Since most of current investigations for virus-host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected proteomic datasets from human lung, colon, kidney, liver, and heart, we constructed a virus-receptor network, a virus-interaction network, and a virus-perturbation network. In the tissue-specific networks associated with virus-host crosstalk, both common and different key hubs are revealed in diverse tissues. Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug targets to rescue multi-organ injury and deal with inflammation. Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction. The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues, and the treatment of COVID-19 would be a complex task.
|*SARS-CoV-2/pathogenicity/physiology[MESH]
|COVID-19/*metabolism/*virology[MESH]
|Cell Cycle Proteins/metabolism[MESH]
|Colon/metabolism/virology[MESH]
|Heart/virology[MESH]
|Host Microbial Interactions/*physiology[MESH]
|Humans[MESH]
|Kidney/metabolism/virology[MESH]
|Liver/metabolism/virology[MESH]
|Lung/metabolism/virology[MESH]
|Membrane Proteins/metabolism[MESH]
|Metabolic Networks and Pathways[MESH]
|Myocardium/metabolism[MESH]
|Pandemics[MESH]
|Protein Interaction Maps[MESH]
|Proteome/*metabolism[MESH]
|Proteomics[MESH]
|Receptor-Interacting Protein Serine-Threonine Kinases/metabolism[MESH]