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10.1038/s41467-020-17318-x

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suck abstract from ncbi


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pmid32641730      Nat+Commun 2020 ; 11 (1): 3500
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  • Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital #MMPMID32641730
  • Garcia-Basteiro AL; Moncunill G; Tortajada M; Vidal M; Guinovart C; Jimenez A; Santano R; Sanz S; Mendez S; Llupia A; Aguilar R; Alonso S; Barrios D; Carolis C; Cistero P; Choliz E; Cruz A; Fochs S; Jairoce C; Hecht J; Lamoglia M; Martinez MJ; Mitchell RA; Ortega N; Pey N; Puyol L; Ribes M; Rosell N; Sotomayor P; Torres S; Williams S; Barroso S; Vilella A; Munoz J; Trilla A; Varela P; Mayor A; Dobano C
  • Nat Commun 2020[Jul]; 11 (1): 3500 PMID32641730show ga
  • Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1-12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8-14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings.
  • |*Health Personnel[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Asymptomatic Infections/epidemiology[MESH]
  • |Betacoronavirus/genetics/*immunology/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/blood/diagnosis/*epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Occupational Health[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/diagnosis/*epidemiology[MESH]
  • |RNA, Viral/blood[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Seroepidemiologic Studies[MESH]


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