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10.1038/s41467-020-17240-2 http://scihub22266oqcxt.onion/10.1038/s41467-020-17240-2 32641700!7343781!32641700     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3410 Nephropedia Template TP {{tp|p=32641700|t=2020. Immunological and inflammatory profiles in mild and severe cases of COVID-19 |pdf=|usr=}}{{32641700}} gab.com Text Immunological and inflammatory profiles in mild and severe cases of COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32641700 #FOAvip COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. Twit Text FOAVip Immunological and inflammatory profiles in mild and severe cases of COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32641700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32641700 #FOAvip English Wikipedia <ref>{{Cite pmid|32641700}}</ref> Immunological and inflammatory profiles in mild and severe cases of COVID-19 #MMPMID32641700 Song JW; Zhang C; Fan X; Meng FP; Xu Z; Xia P; Cao WJ; Yang T; Dai XP; Wang SY; Xu RN; Jiang TJ; Li WG; Zhang DW; Zhao P; Shi M; Agrati C; Ippolito G; Maeurer M; Zumla A; Wang FS; Zhang JY Nat Commun 2020[Jul]; 11 (1): 3410 PMID32641700show ga COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |Biomarkers/metabolism[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |CD8-Positive T-Lymphocytes/immunology/pathology[MESH] |COVID-19[MESH] |Chemotaxis, Leukocyte[MESH] |China/epidemiology[MESH] |Coronavirus Infections/blood/*immunology/*pathology/virology[MESH] |Cytokines/blood[MESH] |Female[MESH] |Humans[MESH] |Inflammation[MESH] |Killer Cells, Natural/immunology/pathology[MESH] |Leukocyte Count[MESH] |Lung/immunology/virology[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/*pathology/virology[MESH]Immunological and inflammatory profiles in mild and severe cases of CO(epmc).pdf DeepDyve Pubget Overpricing