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10.1016/j.fertnstert.2020.06.026 http://scihub22266oqcxt.onion/10.1016/j.fertnstert.2020.06.026 32641214!7298504!32641214     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32641214&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle |pdf=|usr=}}{{32641214}} gab.com Text SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle JO: Fertil Steril http://www.kidney.de/pget.php?&tw=1&pmid=32641214 #FOAvip OBJECTIVE: To determine the susceptibility of the endometrium to infection by-and thereby potential damage from-SARS-CoV-2. DESIGN: Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic data sets. SETTING: Infertility research department affiliated with a public hospital. PATIENT(S): Gene expression data from five studies in 112 patients with normal endometrium collected throughout the menstrual cycle. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Gene expression and correlation between viral infectivity genes and age throughout the menstrual cycle. RESULT(S): Gene expression was high for TMPRSS4, CTSL, CTSB, FURIN, MX1, and BSG; medium for TMPRSS2; and low for ACE2. ACE2, TMPRSS4, CTSB, CTSL, and MX1 expression increased toward the window of implantation. TMPRSS4 expression was positively correlated with ACE2, CTSB, CTSL, MX1, and FURIN during several cycle phases; TMPRSS2 was not statistically significantly altered across the cycle. ACE2, TMPRSS4, CTSB, CTSL, BSG, and MX1 expression increased with age, especially in early phases of the cycle. CONCLUSION(S): Endometrial tissue is likely safe from SARS-CoV-2 cell entry based on ACE2 and TMPRSS2 expression, but susceptibility increases with age. Further, TMPRSS4, along with BSG-mediated viral entry into cells, could imply a susceptible environment for SARS-CoV-2 entry via different mechanisms. Additional studies are warranted to determine the true risk of endometrial infection by SARS-CoV-2 and implications for fertility treatments. Twit Text FOAVip SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle ????Fertil Steril http://www.kidney.de/pget.php?&tw=1&pmid=32641214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32641214 #FOAvip English Wikipedia <ref>{{Cite pmid|32641214}}</ref> SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle #MMPMID32641214 Henarejos-Castillo I; Sebastian-Leon P; Devesa-Peiro A; Pellicer A; Diaz-Gimeno P Fertil Steril 2020[Aug]; 114 (2): 223-232 PMID32641214show ga OBJECTIVE: To determine the susceptibility of the endometrium to infection by-and thereby potential damage from-SARS-CoV-2. DESIGN: Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic data sets. SETTING: Infertility research department affiliated with a public hospital. PATIENT(S): Gene expression data from five studies in 112 patients with normal endometrium collected throughout the menstrual cycle. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Gene expression and correlation between viral infectivity genes and age throughout the menstrual cycle. RESULT(S): Gene expression was high for TMPRSS4, CTSL, CTSB, FURIN, MX1, and BSG; medium for TMPRSS2; and low for ACE2. ACE2, TMPRSS4, CTSB, CTSL, and MX1 expression increased toward the window of implantation. TMPRSS4 expression was positively correlated with ACE2, CTSB, CTSL, MX1, and FURIN during several cycle phases; TMPRSS2 was not statistically significantly altered across the cycle. ACE2, TMPRSS4, CTSB, CTSL, BSG, and MX1 expression increased with age, especially in early phases of the cycle. CONCLUSION(S): Endometrial tissue is likely safe from SARS-CoV-2 cell entry based on ACE2 and TMPRSS2 expression, but susceptibility increases with age. Further, TMPRSS4, along with BSG-mediated viral entry into cells, could imply a susceptible environment for SARS-CoV-2 entry via different mechanisms. Additional studies are warranted to determine the true risk of endometrial infection by SARS-CoV-2 and implications for fertility treatments. |*Gene Expression Regulation, Viral[MESH] |Adult[MESH] |Age Factors[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/genetics/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/genetics/*metabolism[MESH] |Endometrium/*metabolism/*virology[MESH] |Female[MESH] |Humans[MESH] |Menstrual Cycle[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/biosynthesis/genetics[MESH] |Pneumonia, Viral/genetics/*metabolism[MESH] |Risk Assessment/methods[MESH] |SARS-CoV-2[MESH] |Virus Internalization[MESH]SARS-CoV-2 infection risk assessment in the endometrium: viral infecti(epmc).pdf DeepDyve Pubget Overpricing