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10.1002/JLB.5COVR0620-306R http://scihub22266oqcxt.onion/10.1002/JLB.5COVR0620-306R 32640487!7361550!32640487     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 2021 ; 109 (1): 49-53 Nephropedia Template TP {{tp|p=32640487|t=2021. BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy |pdf=|usr=}}{{32640487}} gab.com Text BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=32640487 #FOAvip Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy. Twit Text FOAVip BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=32640487 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32640487 #FOAvip English Wikipedia <ref>{{Cite pmid|32640487}}</ref> BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy #MMPMID32640487 McGee MC; August A; Huang W J Leukoc Biol 2021[Jan]; 109 (1): 49-53 PMID32640487show ga Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy. |*Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors/immunology/metabolism[MESH] |*COVID-19 Drug Treatment[MESH] |*Lymphopenia/drug therapy/enzymology/immunology[MESH] |*SARS-CoV-2/immunology/metabolism[MESH] |*Signal Transduction/drug effects/immunology[MESH] |COVID-19/enzymology/immunology[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Immunity, Innate/drug effects[MESH]BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia fo(epmc).pdf DeepDyve Pubget Overpricing