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10.1016/j.dsx.2020.06.056 http://scihub22266oqcxt.onion/10.1016/j.dsx.2020.06.056 32640416!7326443!32640416     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+Syndr 2020 ; 14 (5): 1043-1051 Nephropedia Template TP {{tp|p=32640416|t=2020. COVID-19 and ethnicity: A novel pathophysiological role for inflammation |pdf=|usr=}}{{32640416}} gab.com Text COVID-19 and ethnicity: A novel pathophysiological role for inflammation JO: Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32640416 #FOAvip INTRODUCTION: There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population. METHODS: Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18(th) June 2020. These databases were searched using keywords including: 'COVID-19' or 'Black and Minority Ethnic' or 'Inflammation'. A narrative review was synthesized using these included articles. RESULTS: We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population. CONCLUSION: Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this. Twit Text FOAVip COVID-19 and ethnicity: A novel pathophysiological role for inflammation ????Diabetes Metab Syndr http://www.kidney.de/pget.php?&tw=1&pmid=32640416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32640416 #FOAvip English Wikipedia <ref>{{Cite pmid|32640416}}</ref> COVID-19 and ethnicity: A novel pathophysiological role for inflammation #MMPMID32640416 Vepa A; Bae JP; Ahmed F; Pareek M; Khunti K Diabetes Metab Syndr 2020[Sep]; 14 (5): 1043-1051 PMID32640416show ga INTRODUCTION: There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population. METHODS: Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18(th) June 2020. These databases were searched using keywords including: 'COVID-19' or 'Black and Minority Ethnic' or 'Inflammation'. A narrative review was synthesized using these included articles. RESULTS: We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population. CONCLUSION: Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this. |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |Cardiovascular Diseases/*physiopathology[MESH] |Coronavirus Infections/*mortality/physiopathology/virology[MESH] |Ethnicity/*statistics & numerical data[MESH] |Humans[MESH] |Incidence[MESH] |Infections/*physiopathology[MESH] |Inflammation/*epidemiology/virology[MESH] |Obesity/*physiopathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*mortality/physiopathology/virology[MESH] |SARS-CoV-2[MESH] |Stress, Psychological/*physiopathology[MESH] |Survival Rate[MESH]COVID-19 and ethnicity: A novel pathophysiological role for inflammati(epmc).pdf DeepDyve Pubget Overpricing