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10.1016/j.ygeno.2020.07.001

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32640274!7335631!32640274
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suck abstract from ncbi


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pmid32640274      Genomics 2020 ; 112 (6): 3890-3892
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  • SARS-CoV2 envelope protein: non-synonymous mutations and its consequences #MMPMID32640274
  • Hassan SS; Choudhury PP; Roy B
  • Genomics 2020[Nov]; 112 (6): 3890-3892 PMID32640274show ga
  • In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.
  • |*Mutation[MESH]
  • |COVID-19/*virology[MESH]
  • |Coronavirus Envelope Proteins/chemistry/*genetics/*metabolism[MESH]
  • |Genome, Viral[MESH]
  • |Humans[MESH]
  • |Membrane Proteins/metabolism[MESH]
  • |Nucleoside-Phosphate Kinase/metabolism[MESH]


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