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10.1016/j.celrep.2020.107858 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.107858 32640224!7341696!32640224     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32640224&cmd=llinks): Failed to open stream: HTTP request failed! 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Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner |pdf=|usr=}}{{32640224}} gab.com Text Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32640224 #FOAvip During mammalian meiotic prophase I, programmed DNA double-strand breaks are repaired by non-crossover or crossover events, the latter predominantly occurring via the class I crossover pathway and requiring the cyclin N-terminal domain-containing 1(CNTD1) protein. Using an epitope-tagged Cntd1 allele, we detect a short isoform of CNTD1 in vivo that lacks a predicted N-terminal cyclin domain and does not bind cyclin-dependent kinases. Instead, we find that the short-form CNTD1 variant associates with components of the replication factor C (RFC) machinery to facilitate crossover formation, and with the E2 ubiquitin conjugating enzyme, CDC34, to regulate ubiquitylation and subsequent degradation of the WEE1 kinase, thereby modulating cell-cycle progression. We propose that these interactions facilitate a role for CNTD1 as a stop-go regulator during prophase I, ensuring accurate and complete crossover formation before allowing metaphase progression and the first meiotic division. Twit Text FOAVip Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32640224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32640224 #FOAvip English Wikipedia <ref>{{Cite pmid|32640224}}</ref> Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner #MMPMID32640224 Gray S; Santiago ER; Chappie JS; Cohen PE Cell Rep 2020[Jul]; 32 (1): 107858 PMID32640224show ga During mammalian meiotic prophase I, programmed DNA double-strand breaks are repaired by non-crossover or crossover events, the latter predominantly occurring via the class I crossover pathway and requiring the cyclin N-terminal domain-containing 1(CNTD1) protein. Using an epitope-tagged Cntd1 allele, we detect a short isoform of CNTD1 in vivo that lacks a predicted N-terminal cyclin domain and does not bind cyclin-dependent kinases. Instead, we find that the short-form CNTD1 variant associates with components of the replication factor C (RFC) machinery to facilitate crossover formation, and with the E2 ubiquitin conjugating enzyme, CDC34, to regulate ubiquitylation and subsequent degradation of the WEE1 kinase, thereby modulating cell-cycle progression. We propose that these interactions facilitate a role for CNTD1 as a stop-go regulator during prophase I, ensuring accurate and complete crossover formation before allowing metaphase progression and the first meiotic division. |*Crossing Over, Genetic[MESH] |*Meiosis[MESH] |Alleles[MESH] |Animals[MESH] |Cell Nucleus/metabolism[MESH] |Cyclin-Dependent Kinases/metabolism[MESH] |Cyclins/chemistry/genetics/*metabolism[MESH] |Epitope Mapping[MESH] |M Phase Cell Cycle Checkpoints[MESH] |Male[MESH] |Meiotic Prophase I[MESH] |Metaphase[MESH] |Mice, Inbred C57BL[MESH] |Mutation/genetics[MESH] |Pachytene Stage[MESH] |Proliferating Cell Nuclear Antigen/metabolism[MESH] |Replication Protein C/metabolism[MESH]Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Fo(epmc).pdf DeepDyve Pubget Overpricing