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10.1021/acschemneuro.0c00335

http://scihub22266oqcxt.onion/10.1021/acschemneuro.0c00335
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32639711!ä!32639711

suck abstract from ncbi


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pmid32639711      ACS+Chem+Neurosci 2020 ; 11 (15): 2137-2144
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  • CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection #MMPMID32639711
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  • ACS Chem Neurosci 2020[Aug]; 11 (15): 2137-2144 PMID32639711show ga
  • Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier.
  • |*Betacoronavirus/drug effects[MESH]
  • |Adenosine Monophosphate/administration & dosage/analogs & derivatives/metabolism[MESH]
  • |Alanine/administration & dosage/analogs & derivatives/metabolism[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents/administration & dosage/metabolism[MESH]
  • |Antiviral Agents/administration & dosage/metabolism[MESH]
  • |Blood-Brain Barrier/drug effects/*metabolism/virology[MESH]
  • |Brain/drug effects/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Central Nervous System Agents/administration & dosage/metabolism[MESH]
  • |Coronavirus Infections/*drug therapy/*metabolism[MESH]
  • |Drug Evaluation, Preclinical/methods[MESH]
  • |Humans[MESH]
  • |Methylprednisolone/administration & dosage/metabolism[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/*metabolism[MESH]
  • |SARS-CoV-2[MESH]


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