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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Histochem+Cytochem 2020 ; 68 (12): 907-927 Nephropedia Template TP
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The Inter-alpha-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology #MMPMID32639183
Lord MS; Melrose J; Day AJ; Whitelock JM
J Histochem Cytochem 2020[Dec]; 68 (12): 907-927 PMID32639183show ga
Inter-alpha-trypsin inhibitor (IalphaI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution. IalphaI is a complex containing the proteoglycan bikunin to which heavy chain proteins are covalently attached to the chondroitin sulfate chain. Besides its matrix protective activity through protease inhibitory action, IalphaI family members interact with extracellular matrix molecules and most notably hyaluronan, inhibit complement, and provide cell regulatory functions. Recent evidence for the diverse roles of the IalphaI family in both biology and pathology is reviewed and gives insight into their pivotal roles in tissue homeostasis. In addition, the clinical uses of these molecules are explored, such as in the treatment of inflammatory conditions including sepsis and Kawasaki disease, which has recently been associated with severe acute respiratory syndrome coronavirus 2 infection in children.