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10.3389/fcimb.2020.00300 http://scihub22266oqcxt.onion/10.3389/fcimb.2020.00300 32637365!7318800!32637365     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Infect+Microbiol 2020 ; 10 (ä): 300 Nephropedia Template TP {{tp|p=32637365|t=2020. Participation of the IL-10RB Related Cytokines, IL-22 and IFN-lambda in Defense of the Airway Mucosal Barrier |pdf=|usr=}}{{32637365}} gab.com Text Participation of the IL-10RB Related Cytokines, IL-22 and IFN-lambda in Defense of the Airway Mucosal Barrier JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32637365 #FOAvip The airway epithelial barrier is a major barrier protecting against clinically significant infections of the lung. Its integrity is often compromised due to mechanical, chemical, or infectious causes. Opportunistic bacterial pathogens are poised to cause parenchymal infection and become difficult to eradicate due to adaptive metabolic changes, biofilm formation, and the acquisition of antimicrobial resistance and fitness genes. Enhancing mucosal defenses by modulating the cytokines that regulate barrier functions, such as interleukin-22 (IL-22) and interferon-lambda (IFN-lambda), members of the IL-10 family of cytokines, is an attractive approach to prevent these infections that are associated with high morbidity and mortality. These cytokines both signal through the cognate receptor IL-10RB, have related protein structures and common downstream signaling suggesting shared roles in host respiratory defense. They are typically co-expressed in multiple models of infections, but with differing kinetics. IL-22 has an important role in the producing antimicrobial peptides, upregulating expression of junctional proteins in the airway epithelium and working in concert with other inflammatory cytokines such as IL-17. Conversely, IFN-lambda, a potent antiviral in influenza infection with pro-inflammatory properties, appears to decrease junctional integrity allowing for bacterial and immune cell translocation. The effects of these cytokines are pleotropic, with pathogen and tissue specific consequences. Understanding how these cytokines work in the mucosal defenses of the respiratory system may suggest potential targets to prevent invasive infections of the damaged lung. Twit Text FOAVip Participation of the IL-10RB Related Cytokines, IL-22 and IFN-lambda in Defense of the Airway Mucosal Barrier ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32637365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32637365 #FOAvip English Wikipedia <ref>{{Cite pmid|32637365}}</ref> Participation of the IL-10RB Related Cytokines, IL-22 and IFN-lambda in Defense of the Airway Mucosal Barrier #MMPMID32637365 Ahn D; Prince A Front Cell Infect Microbiol 2020[]; 10 (ä): 300 PMID32637365show ga The airway epithelial barrier is a major barrier protecting against clinically significant infections of the lung. Its integrity is often compromised due to mechanical, chemical, or infectious causes. Opportunistic bacterial pathogens are poised to cause parenchymal infection and become difficult to eradicate due to adaptive metabolic changes, biofilm formation, and the acquisition of antimicrobial resistance and fitness genes. Enhancing mucosal defenses by modulating the cytokines that regulate barrier functions, such as interleukin-22 (IL-22) and interferon-lambda (IFN-lambda), members of the IL-10 family of cytokines, is an attractive approach to prevent these infections that are associated with high morbidity and mortality. These cytokines both signal through the cognate receptor IL-10RB, have related protein structures and common downstream signaling suggesting shared roles in host respiratory defense. They are typically co-expressed in multiple models of infections, but with differing kinetics. IL-22 has an important role in the producing antimicrobial peptides, upregulating expression of junctional proteins in the airway epithelium and working in concert with other inflammatory cytokines such as IL-17. Conversely, IFN-lambda, a potent antiviral in influenza infection with pro-inflammatory properties, appears to decrease junctional integrity allowing for bacterial and immune cell translocation. The effects of these cytokines are pleotropic, with pathogen and tissue specific consequences. Understanding how these cytokines work in the mucosal defenses of the respiratory system may suggest potential targets to prevent invasive infections of the damaged lung. |Coronavirus Infections/immunology[MESH] |Humans[MESH] |Influenza, Human/immunology[MESH] |Interferon-gamma/*immunology[MESH] |Interleukin-10 Receptor beta Subunit/*immunology[MESH] |Interleukin-22[MESH] |Interleukins/*immunology[MESH] |Klebsiella Infections/immunology[MESH] |Klebsiella pneumoniae/immunology[MESH] |Pseudomonas aeruginosa/immunology[MESH] |Respiratory Mucosa/*immunology/microbiology[MESH] |Staphylococcal Infections/immunology[MESH] |Staphylococcus aureus/immunology[MESH]Participation of the IL-10RB Related Cytokines, IL-22 and IFN-lambda i(epmc).pdf DeepDyve Pubget Overpricing