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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Pharmacol 2020 ; 11 (ä): 959 Nephropedia Template TP
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Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19 #MMPMID32636755
Belladonna ML; Orabona C
Front Pharmacol 2020[]; 11 (ä): 959 PMID32636755show ga
Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.