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10.1038/s41580-020-0259-3 http://scihub22266oqcxt.onion/10.1038/s41580-020-0259-3 32636524!7339799!32636524     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2020 ; 21 (10): 571-584 Nephropedia Template TP {{tp|p=32636524|t=2020. Human organoids: model systems for human biology and medicine |pdf=|usr=}}{{32636524}} gab.com Text Human organoids: model systems for human biology and medicine JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=32636524 #FOAvip The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids - which are stem cell-derived 3D culture systems - it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study of human disease and complement animal models. Human organoids have been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated from patient biopsy samples. This Review discusses the applications, advantages and disadvantages of human organoids as models of development and disease and outlines the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments. Twit Text FOAVip Human organoids: model systems for human biology and medicine ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=32636524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32636524 #FOAvip English Wikipedia <ref>{{Cite pmid|32636524}}</ref> Human organoids: model systems for human biology and medicine #MMPMID32636524 Kim J; Koo BK; Knoblich JA Nat Rev Mol Cell Biol 2020[Oct]; 21 (10): 571-584 PMID32636524show ga The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids - which are stem cell-derived 3D culture systems - it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study of human disease and complement animal models. Human organoids have been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated from patient biopsy samples. This Review discusses the applications, advantages and disadvantages of human organoids as models of development and disease and outlines the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments. |Animals[MESH] |Biology/*methods[MESH] |Communicable Diseases/pathology[MESH] |Genetic Diseases, Inborn/pathology[MESH] |Genetic Engineering/methods[MESH] |Humans[MESH] |Medicine/*methods[MESH] |Neoplasms/pathology[MESH] |Organoids/*physiology[MESH]Human organoids: model systems for human biology and medicine (epmc).pdf DeepDyve Pubget Overpricing