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10.1038/s41422-020-0364-z http://scihub22266oqcxt.onion/10.1038/s41422-020-0364-z 32636454!7364749!32636454     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2020 ; 30 (8): 670-677 Nephropedia Template TP {{tp|p=32636454|t=2020. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques |pdf=|usr=}}{{32636454}} gab.com Text Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=32636454 #FOAvip The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). However, the dynamics of viral infection, replication and shedding are poorly understood. Here, we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2. After intratracheal inoculation, the first peak of viral RNA was observed in oropharyngeal swabs one day post infection (1 d.p.i.), mainly from the input of the inoculation, while the second peak occurred at 5 d.p.i., which reflected on-site replication in the respiratory tract. Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals, characterized by hyperemia and edema, and infiltration of monocytes and lymphocytes in alveoli. We also identified SARS-CoV-2 RNA in respiratory tract tissues, including trachea, bronchus and lung; and viruses were also re-isolated from oropharyngeal swabs, bronchus and lung, respectively. Furthermore, we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2. The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. Twit Text FOAVip Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=32636454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32636454 #FOAvip English Wikipedia <ref>{{Cite pmid|32636454}}</ref> Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques #MMPMID32636454 Shan C; Yao YF; Yang XL; Zhou YW; Gao G; Peng Y; Yang L; Hu X; Xiong J; Jiang RD; Zhang HJ; Gao XX; Peng C; Min J; Chen Y; Si HR; Wu J; Zhou P; Wang YY; Wei HP; Pang W; Hu ZF; Lv LB; Zheng YT; Shi ZL; Yuan ZM Cell Res 2020[Aug]; 30 (8): 670-677 PMID32636454show ga The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). However, the dynamics of viral infection, replication and shedding are poorly understood. Here, we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2. After intratracheal inoculation, the first peak of viral RNA was observed in oropharyngeal swabs one day post infection (1 d.p.i.), mainly from the input of the inoculation, while the second peak occurred at 5 d.p.i., which reflected on-site replication in the respiratory tract. Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals, characterized by hyperemia and edema, and infiltration of monocytes and lymphocytes in alveoli. We also identified SARS-CoV-2 RNA in respiratory tract tissues, including trachea, bronchus and lung; and viruses were also re-isolated from oropharyngeal swabs, bronchus and lung, respectively. Furthermore, we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2. The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. |*Disease Models, Animal[MESH] |Animals[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |Betacoronavirus/*genetics/*immunology/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/diagnostic imaging/*pathology/virology[MESH] |Female[MESH] |Immunohistochemistry[MESH] |Macaca mulatta/*virology[MESH] |Male[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/diagnostic imaging/*pathology/virology[MESH] |RNA, Viral/genetics[MESH] |Radiography, Thoracic[MESH] |Real-Time Polymerase Chain Reaction[MESH] |SARS-CoV-2[MESH] |Viral Load[MESH]Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhes(epmc).pdf DeepDyve Pubget Overpricing