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10.1136/jitc-2020-001119

http://scihub22266oqcxt.onion/10.1136/jitc-2020-001119
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32636240!7342862!32636240
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suck abstract from ncbi


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pmid32636240      J+Immunother+Cancer 2020 ; 8 (2): ä
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  • BCG vaccine and COVID-19: implications for infection prophylaxis and cancer immunotherapy #MMPMID32636240
  • Koti M; Morales A; Graham CH; Siemens DR
  • J Immunother Cancer 2020[Jul]; 8 (2): ä PMID32636240show ga
  • The COVID-19 pandemic has killed over 400 000 people globally. Ecological evidence indicates that countries with national universal BCG vaccination programs for tuberculosis (TB) prevention have a much lower incidence of severe COVID-19 and mortality compared with those that do not have such programs. BCG is a century old vaccine used for TB prevention via infant/childhood vaccination in lowto middle-income countries with high infection prevalence rate and is known to reduce all-cause neonatal mortality. BCG remains the standard immunotherapy treatment for patients with high-risk non-muscle invasive bladder cancer globally for more than 44 years. Several trials are, therefore, investigating BCG as a prophylactic against COVID-19 in healthcare workers and the elderly. In this commentary, we discuss the potential mechanisms that may underlie BCG associated heterologous protection with a focus on tertiary lymphoid structure (TLS) organogenesis. Given the significance of TLSs in mucosal immunity, their association with positive prognosis and response to immune checkpoint blockade with a critical role of Type I interferon (IFN-1) in inducing these, we also discuss potentiating TLS formation as a promising approach to enhance anti-tumor immunity. We propose that lessons learned from BCG immunotherapy success could be applied to not only augment such microbe-based therapeutics but also lead to similar adjunctive IFN-1 activating approaches to improve response to immune checkpoint blockade therapy in cancer.
  • |*Betacoronavirus[MESH]
  • |BCG Vaccine/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/immunology/*prevention & control[MESH]
  • |Humans[MESH]
  • |Immunotherapy[MESH]
  • |Interferon Type I/*immunology[MESH]
  • |Neoplasms/immunology/*therapy[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/immunology/*prevention & control[MESH]


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