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10.1016/j.jdiacomp.2020.107666

http://scihub22266oqcxt.onion/10.1016/j.jdiacomp.2020.107666
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suck abstract from ncbi


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pmid32636061      J+Diabetes+Complications 2020 ; 34 (10): 107666
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  • Clinical analysis of risk factors for severe COVID-19 patients with type 2 diabetes #MMPMID32636061
  • Zhang Q; Wei Y; Chen M; Wan Q; Chen X
  • J Diabetes Complications 2020[Oct]; 34 (10): 107666 PMID32636061show ga
  • AIMS: To describe characteristics of COVID-19 patients with type 2 diabetes and to analyze risk factors for severity. METHODS: Demographics, comorbidities, symptoms, laboratory findings, treatments and outcomes of COVID-19 patients with diabetes were collected and analyzed. RESULTS: Seventy-fourCOVID-19 patients with diabetes were included. Twenty-seven patients (36.5%) were severe and 10 patients (13.5%) died. Higher levels of blood glucose, serum amyloid A (SAA), C reactive protein and interleukin 6 were associated with severe patients compared to non-severe ones (P<0.05). Levels of albumin, cholesterol, high density lipoprotein, small and dense low density lipoprotein and CD4(+)T lymphocyte counts in severe patients were lower than those in non-severe patients (P<0.05). Logistic regression analysis identified decreased CD4(+)T lymphocyte counts (odds ratio [OR]=0.988, 95%Confidence interval [95%CI] 0.979-0.997) and increased SAA levels (OR=1.029, 95%CI 1.002-1.058) as risk factors for severity of COVID-19 with diabetes (P<0.05). CONCLUSIONS: Type 2 diabetic patients were more susceptible to COVID-19 than overall population, which might be associated with hyperglycemia and dyslipidemia. Aggressive treatment should be suggested, especially when these patients had low CD4(+)T lymphocyte counts and high SAA levels.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*complications/diagnosis/epidemiology[MESH]
  • |Diabetes Mellitus, Type 2/*complications[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/epidemiology[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Survival Rate[MESH]


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