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10.1186/s12967-020-02439-0 http://scihub22266oqcxt.onion/10.1186/s12967-020-02439-0 32635935!7339606!32635935     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32635935&cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach |pdf=|usr=}}{{32635935}} gab.com Text Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32635935 #FOAvip BACKGROUND: The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continents. Hitherto, no antiviral drug is available to combat this viral outbreak. METHODS: Keeping in mind the urgency of the situation, the current study was designed to devise new strategies for drug discovery and/or repositioning against SARS-CoV-2. In the current study, RNA-dependent RNA polymerase (RdRp), which regulates viral replication, is proposed as a potential therapeutic target to inhibit viral infection. RESULTS: Evolutionary studies of whole-genome sequences of SARS-CoV-2 represent high similarity (> 90%) with other SARS viruses. Targeting the RdRp active sites, ASP760 and ASP761, by antiviral drugs could be a potential therapeutic option for inhibition of coronavirus RdRp, and thus viral replication. Target-based virtual screening and molecular docking results show that the antiviral Galidesivir and its structurally similar compounds have shown promise against SARS-CoV-2. CONCLUSIONS: The anti-polymerase drugs predicted here-CID123624208 and CID11687749-may be considered for in vitro and in vivo clinical trials. Twit Text FOAVip Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32635935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32635935 #FOAvip English Wikipedia <ref>{{Cite pmid|32635935}}</ref> Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach #MMPMID32635935 Aftab SO; Ghouri MZ; Masood MU; Haider Z; Khan Z; Ahmad A; Munawar N J Transl Med 2020[Jul]; 18 (1): 275 PMID32635935show ga BACKGROUND: The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continents. Hitherto, no antiviral drug is available to combat this viral outbreak. METHODS: Keeping in mind the urgency of the situation, the current study was designed to devise new strategies for drug discovery and/or repositioning against SARS-CoV-2. In the current study, RNA-dependent RNA polymerase (RdRp), which regulates viral replication, is proposed as a potential therapeutic target to inhibit viral infection. RESULTS: Evolutionary studies of whole-genome sequences of SARS-CoV-2 represent high similarity (> 90%) with other SARS viruses. Targeting the RdRp active sites, ASP760 and ASP761, by antiviral drugs could be a potential therapeutic option for inhibition of coronavirus RdRp, and thus viral replication. Target-based virtual screening and molecular docking results show that the antiviral Galidesivir and its structurally similar compounds have shown promise against SARS-CoV-2. CONCLUSIONS: The anti-polymerase drugs predicted here-CID123624208 and CID11687749-may be considered for in vitro and in vivo clinical trials. |*Computational Biology[MESH] |*Molecular Targeted Therapy[MESH] |Amino Acid Sequence[MESH] |Betacoronavirus/*enzymology/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/*virology[MESH] |Drug Evaluation, Preclinical[MESH] |Evolution, Molecular[MESH] |Humans[MESH] |Ligands[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/*drug therapy/*virology[MESH] |RNA-Dependent RNA Polymerase/chemistry/*metabolism[MESH] |SARS-CoV-2[MESH]Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential the(epmc).pdf DeepDyve Pubget Overpricing