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10.1186/s12916-020-01670-2 http://scihub22266oqcxt.onion/10.1186/s12916-020-01670-2 32635912!7339437!32635912     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2020 ; 18 (1): 209 Nephropedia Template TP {{tp|p=32635912|t=2020. Exploring the acceptability of controlled human infection with SARSCoV2-a public consultation |pdf=|usr=}}{{32635912}} gab.com Text Exploring the acceptability of controlled human infection with SARSCoV2-a public consultation JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32635912 #FOAvip Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. This raises complex questions about the social and ethical acceptability of risk to individuals, given the potential benefit to the wider population, and as such, a study cannot be done without public involvement. We conducted a structured public consultation with 57 individuals aged 20-40 years to understand public attitudes to a CHIM, and pre-requisites for enrolment. The overall response to this strategy was positive, and many would volunteer altruistically. Carefully controlled infection is viewed as safer than natural exposure to wild virus. The prolonged social isolation required for the proposed CHIM is considered an obstacle but not insurmountable, with reasonable compensation and supportive care. Given the significant level of public interest, a CHIM should be done as open science with regular, controlled dissemination of information into the public domain. Importantly, there was a strong view that the final decision whether to conduct a CHIM should be in the hands of qualified and experienced clinician-scientists and the authorities. Twit Text FOAVip Exploring the acceptability of controlled human infection with SARSCoV2-a public consultation ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=32635912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32635912 #FOAvip English Wikipedia <ref>{{Cite pmid|32635912}}</ref> Exploring the acceptability of controlled human infection with SARSCoV2-a public consultation #MMPMID32635912 Gbesemete D; Barker M; Lawrence WT; Watson D; de Graaf H; Read RC BMC Med 2020[Jul]; 18 (1): 209 PMID32635912show ga Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. This raises complex questions about the social and ethical acceptability of risk to individuals, given the potential benefit to the wider population, and as such, a study cannot be done without public involvement. We conducted a structured public consultation with 57 individuals aged 20-40 years to understand public attitudes to a CHIM, and pre-requisites for enrolment. The overall response to this strategy was positive, and many would volunteer altruistically. Carefully controlled infection is viewed as safer than natural exposure to wild virus. The prolonged social isolation required for the proposed CHIM is considered an obstacle but not insurmountable, with reasonable compensation and supportive care. Given the significant level of public interest, a CHIM should be done as open science with regular, controlled dissemination of information into the public domain. Importantly, there was a strong view that the final decision whether to conduct a CHIM should be in the hands of qualified and experienced clinician-scientists and the authorities. |*Attitude to Health[MESH] |Adult[MESH] |Betacoronavirus[MESH] |Biomedical Research/*ethics[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/*prevention & control[MESH] |Drug Development[MESH] |Female[MESH] |Focus Groups[MESH] |Humans[MESH] |Male[MESH] |Pandemics/*prevention & control[MESH] |Patient Selection[MESH] |Pneumonia, Viral/*prevention & control[MESH] |Public Opinion[MESH] |Referral and Consultation[MESH] |SARS-CoV-2[MESH] |United Kingdom[MESH] |Viral Vaccines/*therapeutic use[MESH]Exploring the acceptability of controlled human infection with SARSCoV(epmc).pdf DeepDyve Pubget Overpricing