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10.1016/j.ijid.2020.06.107

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.06.107
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suck abstract from ncbi


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pmid32634589      Int+J+Infect+Dis 2020 ; 98 (ä): 334-346
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  • A potentially effective treatment for COVID-19: A systematic review and meta-analysis of convalescent plasma therapy in treating severe infectious disease #MMPMID32634589
  • Sun M; Xu Y; He H; Zhang L; Wang X; Qiu Q; Sun C; Guo Y; Qiu S; Ma K
  • Int J Infect Dis 2020[Sep]; 98 (ä): 334-346 PMID32634589show ga
  • BACKGROUND: Convalescent plasma (CP) has been used successfully to treat many types of infectious disease, and has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). However, its curative effects and feasibility have yet to be confirmed by formal evaluation and well-designed clinical trials. To explore the effectiveness of treatment and predict the potential effects of CP with COVID-19, studies of different types of infectious disease treated with CP were included in this systematic review and meta-analysis. METHODS: Related studies were obtained from databases and screened according to the inclusion criteria. The data quality was assessed, and the data were extracted and pooled for analysis. RESULTS: 40 studies on CP treatment for infectious diseases were included. Our study found that CP treatment could reduce the risk of mortality, with a low incidence of adverse events, promote the production of antibodies, lead to a decline in viral load, and shorten the disease course. A meta-analysis of 15 controlled studies showed that there was a significantly lower mortality rate in the group treated with CP (pooled OR=0.32; 95% CI=0.19-0.52; p<0.001, I(2)=54%) compared with the control groups. Studies were mostly of low or very low quality, with a moderate or high risk of bias. The sources of clinical and methodological heterogeneity were identified. The exclusion of heterogeneity indicated that the results were stable. CONCLUSIONS: CP therapy has some curative effect and is well tolerated in treating infectious diseases. It is a potentially effective treatment for COVID-19.
  • |Antibodies, Viral/*administration & dosage/immunology[MESH]
  • |Betacoronavirus/immunology/*physiology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Coronavirus Infections/immunology/*therapy/virology[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Pandemics[MESH]
  • |Plasma/*chemistry[MESH]
  • |Pneumonia, Viral/immunology/*therapy/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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