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10.1016/j.virusres.2020.198088 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198088 32634445!7345311!32634445     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Res 2020 ; 286 (ä): 198088 Nephropedia Template TP {{tp|p=32634445|t=2020. Pyruvate affects inflammatory responses of macrophages during influenza A virus infection |pdf=|usr=}}{{32634445}} gab.com Text Pyruvate affects inflammatory responses of macrophages during influenza A virus infection JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32634445 #FOAvip Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1beta, and TNF-alpha). Sodium pyruvate did not inhibit viral RNA replication. Instead, the addition of sodium pyruvate alters cellular metabolism and diminished mitochondrial reactive oxygen species (ROS) production and lowered immune signaling. Overall, sodium pyruvate affects the immune response produced by macrophages but does not inhibit virus replication. Twit Text FOAVip Pyruvate affects inflammatory responses of macrophages during influenza A virus infection ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32634445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32634445 #FOAvip English Wikipedia <ref>{{Cite pmid|32634445}}</ref> Pyruvate affects inflammatory responses of macrophages during influenza A virus infection #MMPMID32634445 Abusalamah H; Reel JM; Lupfer CR Virus Res 2020[Sep]; 286 (ä): 198088 PMID32634445show ga Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media during infection of mouse bone marrow derived macrophages with influenza A virus impaired cytokine production (IL-6, IL-1beta, and TNF-alpha). Sodium pyruvate did not inhibit viral RNA replication. Instead, the addition of sodium pyruvate alters cellular metabolism and diminished mitochondrial reactive oxygen species (ROS) production and lowered immune signaling. Overall, sodium pyruvate affects the immune response produced by macrophages but does not inhibit virus replication. |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Cells, Cultured[MESH] |Culture Media/chemistry[MESH] |Gene Expression[MESH] |Immunity, Innate/*drug effects[MESH] |Inflammasomes/drug effects/metabolism[MESH] |Inflammation/immunology/*virology[MESH] |Influenza A virus/drug effects[MESH] |Macrophages/*drug effects/*immunology/virology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Pyruvic Acid/*pharmacology[MESH]Pyruvate affects inflammatory responses of macrophages during influenz(epmc).pdf DeepDyve Pubget Overpricing