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10.1016/j.ejphar.2020.173340 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173340 32634441!7334664!32634441     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2020 ; 883 (ä): 173340 Nephropedia Template TP {{tp|p=32634441|t=2020. Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor |pdf=|usr=}}{{32634441}} gab.com Text Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32634441 #FOAvip Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. a cytokine storm. For sepsis involving gram-negative bacteria, macrophages recognize lipopolysaccharide (LPS) shed from the bacteria, activating Toll-like-receptor 4 (TLR4), and triggering a cytokine storm. Glycogen synthase kinase-3 (GSK-3) is a highly active kinase that has been implicated in LPS-induced cytokine production. Thus, compounds that inhibit GSK-3 could be potential therapeutics for sepsis. Our group has recently described a novel and highly selective inhibitor of GSK-3 termed COB-187. In the present study, using THP-1 macrophages, we evaluated the ability of COB-187 to attenuate LPS-induced cytokine production. We found that COB-187 significantly reduced, at the protein and mRNA levels, cytokines induced by LPS (e.g. IL-6, TNF-alpha, IL-1beta, CXCL10, and IFN-beta). Further, the data suggest that the inhibition could be due, at least in part, to COB-187 reducing NF-kappaB (p65/p50) DNA binding activity as well as reducing IRF-3 phosphorylation at Serine 396. Thus, COB-187 appears to be a potent inhibitor of the cytokine storm induced by LPS. Twit Text FOAVip Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32634441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32634441 #FOAvip English Wikipedia <ref>{{Cite pmid|32634441}}</ref> Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor #MMPMID32634441 Noori MS; Courreges MC; Bergmeier SC; McCall KD; Goetz DJ Eur J Pharmacol 2020[Sep]; 883 (ä): 173340 PMID32634441show ga Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. a cytokine storm. For sepsis involving gram-negative bacteria, macrophages recognize lipopolysaccharide (LPS) shed from the bacteria, activating Toll-like-receptor 4 (TLR4), and triggering a cytokine storm. Glycogen synthase kinase-3 (GSK-3) is a highly active kinase that has been implicated in LPS-induced cytokine production. Thus, compounds that inhibit GSK-3 could be potential therapeutics for sepsis. Our group has recently described a novel and highly selective inhibitor of GSK-3 termed COB-187. In the present study, using THP-1 macrophages, we evaluated the ability of COB-187 to attenuate LPS-induced cytokine production. We found that COB-187 significantly reduced, at the protein and mRNA levels, cytokines induced by LPS (e.g. IL-6, TNF-alpha, IL-1beta, CXCL10, and IFN-beta). Further, the data suggest that the inhibition could be due, at least in part, to COB-187 reducing NF-kappaB (p65/p50) DNA binding activity as well as reducing IRF-3 phosphorylation at Serine 396. Thus, COB-187 appears to be a potent inhibitor of the cytokine storm induced by LPS. |Anti-Inflammatory Agents/*pharmacology[MESH] |Cytokine Release Syndrome/chemically induced/enzymology/genetics/*prevention & control[MESH] |Cytokines/genetics/*metabolism[MESH] |Down-Regulation[MESH] |Glycogen Synthase Kinase 3/*antagonists & inhibitors/metabolism[MESH] |Humans[MESH] |Inflammation Mediators/*metabolism[MESH] |Interferon Regulatory Factor-3/metabolism[MESH] |Lipopolysaccharides/toxicity[MESH] |Macrophages/*drug effects/enzymology[MESH] |NF-kappa B/metabolism[MESH] |Phosphorylation[MESH] |Protein Kinase Inhibitors/*pharmacology[MESH] |Sepsis/chemically induced/enzymology/genetics/prevention & control[MESH] |Signal Transduction[MESH]Modulation of LPS-induced inflammatory cytokine production by a novel (epmc).pdf DeepDyve Pubget Overpricing