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10.1093/labmed/lmaa045

http://scihub22266oqcxt.onion/10.1093/labmed/lmaa045
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32634229!7454829!32634229
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suck abstract from ncbi


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pmid32634229      Lab+Med 2020 ; 51 (5): e66-e70
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  • Laboratory Assay Evaluation Demystified: A Review of Key Factors Influencing Interpretation of Test Results Using Different Assays for SARS-CoV-2 Infection Diagnosis #MMPMID32634229
  • Pham HP; Staley EM; Raju D; Marin MJ; Kim CH
  • Lab Med 2020[Sep]; 51 (5): e66-e70 PMID32634229show ga
  • Laboratory tests are an integral part of the diagnosis and management of patients; however, these tests are far from perfect. Their imperfections can be due to patient health condition, specimen collection, and/or technological difficulty with performing the assay and/or interpretation. To be useful clinically, testing requires calculation of positive predictive values (PPVs) and negative predictive values (NPVs). During the current global pandemic of COVID-19 (coronavirus disease 2019), multiple assays with unknown clinical sensitivity and specificity have been rapidly developed to aid in the diagnosis of the disease. Due to a lack of surveillance testing, the prevalence of COVID-19 remains unknown. Hence, using this situation as an clinical example, the goal of this article is to clarify the key factors that influence the PPV and NPV yielded by diagnostic testing, By doing so, we hope to offer health-care providers information that will help them better understand the potential implications of utilizing these test results in clinical patient management.
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/epidemiology[MESH]
  • |Data Interpretation, Statistical[MESH]
  • |Diagnostic Errors/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Molecular Diagnostic Techniques/methods/*standards[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/epidemiology[MESH]


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