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10.1002/jmv.26264 http://scihub22266oqcxt.onion/10.1002/jmv.26264 32633831!ä!32633831 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (1): 300-310 Nephropedia Template TP {{tp|p=32633831|t=2021. RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target |pdf=|usr=}}{{32633831}} gab.com Text RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32633831 #FOAvip The global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), named coronavirus disease 2019, has infected more than 8.9 million people worldwide. This calls for urgent effective therapeutic measures. RNA-dependent RNA polymerase (RdRp) activity in viral transcription and replication has been recognized as an attractive target to design novel antiviral strategies. Although SARS-CoV-2 shares less genetic similarity with SARS-CoV (~79%) and Middle East respiratory syndrome coronavirus (~50%), the respective RdRps of the three coronaviruses are highly conserved, suggesting that RdRp is a good broad-spectrum antiviral target for coronaviruses. In this review, we discuss the antiviral potential of RdRp inhibitors (mainly nucleoside analogs) with an aim to provide a comprehensive account of drug discovery on SARS-CoV-2. Twit Text FOAVip RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32633831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32633831 #FOAvip English Wikipedia <ref>{{Cite pmid|32633831}}</ref> RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target #MMPMID32633831 Wang Y; Anirudhan V; Du R; Cui Q; Rong L J Med Virol 2021[Jan]; 93 (1): 300-310 PMID32633831show ga The global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), named coronavirus disease 2019, has infected more than 8.9 million people worldwide. This calls for urgent effective therapeutic measures. RNA-dependent RNA polymerase (RdRp) activity in viral transcription and replication has been recognized as an attractive target to design novel antiviral strategies. Although SARS-CoV-2 shares less genetic similarity with SARS-CoV (~79%) and Middle East respiratory syndrome coronavirus (~50%), the respective RdRps of the three coronaviruses are highly conserved, suggesting that RdRp is a good broad-spectrum antiviral target for coronaviruses. In this review, we discuss the antiviral potential of RdRp inhibitors (mainly nucleoside analogs) with an aim to provide a comprehensive account of drug discovery on SARS-CoV-2. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/*virology[MESH] |Enzyme Inhibitors/pharmacology/*therapeutic use[MESH] |Nucleosides/pharmacology/therapeutic use[MESH] |RNA-Dependent RNA Polymerase/*antagonists & inhibitors/genetics/metabolism[MESH]RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target (epmc).pdf DeepDyve Pubget Overpricing