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10.1186/s41747-020-00171-4 http://scihub22266oqcxt.onion/10.1186/s41747-020-00171-4 32632766!7338094!32632766     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32632766&cmd=llinks): Failed to open stream: HTTP request failed! 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Transcatheter drug delivery through bronchial artery for COVID-19: is it fiction or could it come true?|pdf=|usr=}}{{32632766}} gab.com Text Transcatheter drug delivery through bronchial artery for COVID-19: is it fiction or could it come true JO: Eur Radiol Exp http://www.kidney.de/pget.php?&tw=1&pmid=32632766 #FOAvip More than 1,200 active or recruiting clinical trials for novel coronavirus disease 2019 (COVID-19) treatments and vaccines are registered. Many drugs have shown promise for treatment of COVID-19. Nevertheless, up to date, no drugs have been confirmed as a definitive treatment for COVID-19. Trials such as the SOLIDARITY and RECOVERY are ongoing, and first results were announced in favour of therapy with dexamethasone with a significant trend showing greatest benefit among those patients requiring ventilation. The drawbacks of these trials include exposing the patients to drugs with well-documented systemic adverse effects or unknown complications of novel therapies without proof of clinical benefit. We present here the hypothesis that bronchial artery infusion could be an alternative for systemic drug infusion in COVID-19 trials with superadded benefits of high drug concentration and low systemic adverse effects. The concept of this idea has many uncertainties and no current clinical data to support. Perhaps, the technique should be first applied in animal models to determine its safety and calculate the effective dose of the drugs. Guidelines and reviews of pharmacotherapy for COVID-19 should be implemented for this fiction to come true. Twit Text FOAVip Transcatheter drug delivery through bronchial artery for COVID-19: is it fiction or could it come true ????Eur Radiol Exp http://www.kidney.de/pget.php?&tw=1&pmid=32632766 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32632766 #FOAvip English Wikipedia <ref>{{Cite pmid|32632766}}</ref> Transcatheter drug delivery through bronchial artery for COVID-19: is it fiction or could it come true? #MMPMID32632766 Zaitoun MMA; Basha MAA; Elmokadem AH Eur Radiol Exp 2020[Jul]; 4 (1): 42 PMID32632766show ga More than 1,200 active or recruiting clinical trials for novel coronavirus disease 2019 (COVID-19) treatments and vaccines are registered. Many drugs have shown promise for treatment of COVID-19. Nevertheless, up to date, no drugs have been confirmed as a definitive treatment for COVID-19. Trials such as the SOLIDARITY and RECOVERY are ongoing, and first results were announced in favour of therapy with dexamethasone with a significant trend showing greatest benefit among those patients requiring ventilation. The drawbacks of these trials include exposing the patients to drugs with well-documented systemic adverse effects or unknown complications of novel therapies without proof of clinical benefit. We present here the hypothesis that bronchial artery infusion could be an alternative for systemic drug infusion in COVID-19 trials with superadded benefits of high drug concentration and low systemic adverse effects. The concept of this idea has many uncertainties and no current clinical data to support. Perhaps, the technique should be first applied in animal models to determine its safety and calculate the effective dose of the drugs. Guidelines and reviews of pharmacotherapy for COVID-19 should be implemented for this fiction to come true. |*Betacoronavirus[MESH] |*Drug Delivery Systems[MESH] |*Pandemics[MESH] |Antiviral Agents/*administration & dosage[MESH] |Bronchial Arteries[MESH] |COVID-19[MESH] |Catheterization, Peripheral/*methods[MESH] |Coronavirus Infections/*drug therapy/epidemiology[MESH] |Humans[MESH] |Infusions, Intra-Arterial[MESH] |Pneumonia, Viral/*drug therapy/epidemiology[MESH]Transcatheter drug delivery through bronchial artery for COVID-19: is (epmc).pdf DeepDyve Pubget Overpricing