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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 EClinicalMedicine 2020 ; 23 (ä): 100407 Nephropedia Template TP
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Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain #MMPMID32632417
San-Juan R; Barbero P; Fernandez-Ruiz M; Lopez-Medrano F; Lizasoain M; Hernandez-Jimenez P; Silva JT; Ruiz-Ruigomez M; Corbella L; Rodriguez-Goncer I; Folgueira MD; Lalueza A; Batllori E; Mejia I; Forcen L; Lumbreras C; Garcia-Burguillo A; Galindo A; Aguado JM
EClinicalMedicine 2020[Jun]; 23 (ä): 100407 PMID32632417show ga
BACKGROUND: Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce. METHODS: Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain. FINDINGS: COVID-19 pneumonia was diagnosed in 61.5% (32/52) women. Only 18.7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56.3%), with high-flow requirements in six (18.7%). Eight patients (25.0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6.2%). Tocilizumab was administered in five patients (15.6%). Delivery was precipitated due to COVID-19 in three women (9.4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55.6% vs. 0.0%; P-value = 0.003) and serum C-reactive protein (CRP) levels >10 mg/dL (33.0% vs. 0.0%; P-value = 0.05) at admission than those with no oxygen requirements. INTERPRETATION: Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia. FUNDING: Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.