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10.1038/s41585-020-0357-1

http://scihub22266oqcxt.onion/10.1038/s41585-020-0357-1
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suck abstract from ncbi


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pmid32632305      Nat+Rev+Urol 2020 ; 17 (9): 491-492
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  • NICE s rejection of pembrolizumab for platinum-refractory urothelial carcinoma: is there a greater good? #MMPMID32632305
  • Gupta S; Kamat AM
  • Nat Rev Urol 2020[Sep]; 17 (9): 491-492 PMID32632305show ga
  • Anti-PD1 and anti-PDL1 immunotherapy has transformed urothelial carcinoma treatment. Pembrolizumab is the only immunotherapy agent shown to have survival benefit compared with standard chemotherapy after progression on platinum-containing chemotherapy. Initial National Institute for Health and Care Excellence (NICE) approval was based on efficacy data, but the final appraisal report rejected use of pembrolizumab owing to treatment cost.
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Antineoplastic Agents, Immunological/*therapeutic use[MESH]
  • |Antineoplastic Agents/therapeutic use[MESH]
  • |Carboplatin/therapeutic use[MESH]
  • |Carcinoma, Transitional Cell/*drug therapy[MESH]
  • |Cisplatin/therapeutic use[MESH]
  • |Humans[MESH]
  • |Practice Guidelines as Topic[MESH]


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  • suck abstract from ncbi

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