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10.1038/s41467-020-17292-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-17292-4 32632085!7338513!32632085     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32632085&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3434 Nephropedia Template TP {{tp|p=32632085|t=2020. Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia |pdf=|usr=}}{{32632085}} gab.com Text Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naive, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1(+)CD57(+) exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4(+) T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-gamma, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19. Twit Text FOAVip Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip English Wikipedia <ref>{{Cite pmid|32632085}}</ref> Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia #MMPMID32632085 De Biasi S; Meschiari M; Gibellini L; Bellinazzi C; Borella R; Fidanza L; Gozzi L; Iannone A; Lo Tartaro D; Mattioli M; Paolini A; Menozzi M; Milic J; Franceschi G; Fantini R; Tonelli R; Sita M; Sarti M; Trenti T; Brugioni L; Cicchetti L; Facchinetti F; Pietrangelo A; Clini E; Girardis M; Guaraldi G; Mussini C; Cossarizza A Nat Commun 2020[Jul]; 11 (1): 3434 PMID32632085show ga The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naive, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1(+)CD57(+) exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4(+) T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-gamma, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/*immunology[MESH] |Biomarkers/metabolism[MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism/pathology[MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism/pathology[MESH] |COVID-19[MESH] |Cellular Senescence[MESH] |Coronavirus Infections/blood/*immunology/pathology[MESH] |Cytokine Release Syndrome[MESH] |Cytokines/immunology/metabolism[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Italy/epidemiology[MESH] |Lymphocyte Activation[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/pathology[MESH] |SARS-CoV-2[MESH] |T-Lymphocyte Subsets/*immunology/metabolism/pathology[MESH]Marked T cell activation, senescence, exhaustion and skewing towards T(epmc).pdf DeepDyve Pubget Overpricing