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10.1073/pnas.2008373117 http://scihub22266oqcxt.onion/10.1073/pnas.2008373117 32632012!7395516!32632012     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (30): 17513-17515 Nephropedia Template TP {{tp|p=32632012|t=2020. The implications of silent transmission for the control of COVID-19 outbreaks |pdf=|usr=}}{{32632012}} gab.com Text The implications of silent transmission for the control of COVID-19 outbreaks JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32632012 #FOAvip Since the emergence of coronavirus disease 2019 (COVID-19), unprecedented movement restrictions and social distancing measures have been implemented worldwide. The socioeconomic repercussions have fueled calls to lift these measures. In the absence of population-wide restrictions, isolation of infected individuals is key to curtailing transmission. However, the effectiveness of symptom-based isolation in preventing a resurgence depends on the extent of presymptomatic and asymptomatic transmission. We evaluate the contribution of presymptomatic and asymptomatic transmission based on recent individual-level data regarding infectiousness prior to symptom onset and the asymptomatic proportion among all infections. We found that the majority of incidences may be attributable to silent transmission from a combination of the presymptomatic stage and asymptomatic infections. Consequently, even if all symptomatic cases are isolated, a vast outbreak may nonetheless unfold. We further quantified the effect of isolating silent infections in addition to symptomatic cases, finding that over one-third of silent infections must be isolated to suppress a future outbreak below 1% of the population. Our results indicate that symptom-based isolation must be supplemented by rapid contact tracing and testing that identifies asymptomatic and presymptomatic cases, in order to safely lift current restrictions and minimize the risk of resurgence. Twit Text FOAVip The implications of silent transmission for the control of COVID-19 outbreaks ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32632012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32632012 #FOAvip English Wikipedia <ref>{{Cite pmid|32632012}}</ref> The implications of silent transmission for the control of COVID-19 outbreaks #MMPMID32632012 Moghadas SM; Fitzpatrick MC; Sah P; Pandey A; Shoukat A; Singer BH; Galvani AP Proc Natl Acad Sci U S A 2020[Jul]; 117 (30): 17513-17515 PMID32632012show ga Since the emergence of coronavirus disease 2019 (COVID-19), unprecedented movement restrictions and social distancing measures have been implemented worldwide. The socioeconomic repercussions have fueled calls to lift these measures. In the absence of population-wide restrictions, isolation of infected individuals is key to curtailing transmission. However, the effectiveness of symptom-based isolation in preventing a resurgence depends on the extent of presymptomatic and asymptomatic transmission. We evaluate the contribution of presymptomatic and asymptomatic transmission based on recent individual-level data regarding infectiousness prior to symptom onset and the asymptomatic proportion among all infections. We found that the majority of incidences may be attributable to silent transmission from a combination of the presymptomatic stage and asymptomatic infections. Consequently, even if all symptomatic cases are isolated, a vast outbreak may nonetheless unfold. We further quantified the effect of isolating silent infections in addition to symptomatic cases, finding that over one-third of silent infections must be isolated to suppress a future outbreak below 1% of the population. Our results indicate that symptom-based isolation must be supplemented by rapid contact tracing and testing that identifies asymptomatic and presymptomatic cases, in order to safely lift current restrictions and minimize the risk of resurgence. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Asymptomatic Infections/*epidemiology[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Contact Tracing/*statistics & numerical data[MESH] |Coronavirus Infections/epidemiology/*prevention & control/*transmission/virology[MESH] |Female[MESH] |Humans[MESH] |Incidence[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Infection Control/*methods[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/epidemiology/*prevention & control/*transmission/virology[MESH] |Quarantine/*statistics & numerical data[MESH] |SARS-CoV-2[MESH]The implications of silent transmission for the control of COVID-19 ou(epmc).pdf DeepDyve Pubget Overpricing