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10.1128/AAC.01101-20

http://scihub22266oqcxt.onion/10.1128/AAC.01101-20
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32631826!7449177!32631826
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suck abstract from ncbi

pmid32631826      Antimicrob+Agents+Chemother 2020 ; 64 (9): ä
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  • Clinical Trials of Repurposed Antivirals for SARS-CoV-2 #MMPMID32631826
  • Martinez MA
  • Antimicrob Agents Chemother 2020[Aug]; 64 (9): ä PMID32631826show ga
  • The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted the repurposing of drugs on the basis of promising in vitro and therapeutic results with other human coronavirus diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). These repurposed drugs have mainly included remdesivir, favipiravir, lopinavir-ritonavir, ribavirin, interferons, and hydroxychloroquine. Unfortunately, the first open-label, randomized, controlled trials are showing poor efficacy of these repurposed drugs. These results highlight the necessity of identifying and characterizing specific and potent SARS-CoV-2 antivirals.
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Amides/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/immunology/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/immunology/mortality/virology[MESH]
  • |Drug Administration Schedule[MESH]
  • |Drug Combinations[MESH]
  • |Drug Repositioning[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Interferons/*therapeutic use[MESH]
  • |Lopinavir/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/immunology/mortality/virology[MESH]
  • |Pyrazines/therapeutic use[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Ribavirin/*therapeutic use[MESH]
  • |Ritonavir/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Survival Analysis[MESH]


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