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10.1186/s12931-020-01427-8

http://scihub22266oqcxt.onion/10.1186/s12931-020-01427-8
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32631317!7336103!32631317
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suck abstract from ncbi


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pmid32631317      Respir+Res 2020 ; 21 (1): 171
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  • Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia #MMPMID32631317
  • Wu MY; Yao L; Wang Y; Zhu XY; Wang XF; Tang PJ; Chen C
  • Respir Res 2020[Jul]; 21 (1): 171 PMID32631317show ga
  • BACKGROUND: There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated. METHODS: Study was performed in 87 cases confirmed by COVID-19 infection. The serum LDH levels were determined at diagnosis and follow-up visits. The evaluation of clinical response to therapy was based on chest CT scan. We selected the value of LDH around the data of chest CT scan (- 1 ~ + 1 day). RESULTS: At diagnosis, significant differences in LDH levels were found between non-severe and severe group (P < 0.05). It was demonstrated that increase or decrease of LDH was indicative of radiographic progress or improvement (P < 0.05). The time to LDH normalization (5.67 +/- 0.55, days) was positively correlated with the time to radiographic absorption (5.57 +/- 0.65 days, r = 0.53, P < 0.05). Applying the cut-off value of the increase in LDH has good specificity to predict disease progression. CONCLUSIONS: Serum LDH was validated for its potential usefulness as markers for evaluating clinical severity and monitoring treatment response in COVID-19 pneumonia.
  • |*Disease Progression[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*blood/diagnosis/epidemiology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/diagnosis/epidemiology[MESH]
  • |Predictive Value of Tests[MESH]
  • |Radiography, Thoracic/*methods[MESH]
  • |Reproducibility of Results[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Severity of Illness Index[MESH]


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