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10.3390/cells9071583

http://scihub22266oqcxt.onion/10.3390/cells9071583
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32629875!7408139!32629875
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suck abstract from ncbi


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pmid32629875      Cells 2020 ; 9 (7): ä
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  • Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection #MMPMID32629875
  • Labo N; Ohnuki H; Tosato G
  • Cells 2020[Jun]; 9 (7): ä PMID32629875show ga
  • The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has resulted in > 500,000 deaths worldwide, including > 125,000 deaths in the U.S. since its emergence in late December 2019 and June 2020. Neither curative anti-viral drugs nor a protective vaccine is currently available for the treatment and prevention of COVID-19. Recently, new clinical syndromes associated with coagulopathy and vasculopathy have emerged as a cause of sudden death and other serious clinical manifestations in younger patients infected with SARS-CoV-2 infection. Angiotensin converting enzyme 2 (ACE2), the receptor for SARS-CoV-2 and other coronaviruses, is a transmembrane protein expressed by lung alveolar epithelial cells, enterocytes, and vascular endothelial cells, whose physiologic role is to induce the maturation of angiotensin I to generate angiotensin 1-7, a peptide hormone that controls vasoconstriction and blood pressure. In this review, we provide the general context of the molecular and cellular mechanisms of SARS-CoV-2 infection with a focus on endothelial cells, describe the vasculopathy and coagulopathy syndromes in patients with SARS-CoV-2, and outline current understanding of the underlying mechanistic aspects.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus/isolation & purification/physiology[MESH]
  • |Blood Coagulation[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*pathology/virology[MESH]
  • |Coronavirus/physiology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Endothelium, Vascular/metabolism/pathology/virology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Pneumonia, Viral/*pathology/virology[MESH]
  • |SARS-CoV-2[MESH]


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