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10.1111/tid.13401 http://scihub22266oqcxt.onion/10.1111/tid.13401 32629531!7361240!32629531     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32629531&cmd=llinks): Failed to open stream: HTTP request failed! 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Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib |pdf=|usr=}}{{32629531}} gab.com Text Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib JO: Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32629531 #FOAvip Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in severe COVID-19 cases appears to be related to a massive production of pro-inflammatory cytokines. The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID-19; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. We describe a first case of severe COVID-19 developed after hematopoietic stem cell transplantation in a patient with a concomitant chronic GVHD (cGVHD), in which a treatment with ruxolitinib was administered with good tolerance and positive outcome. Twit Text FOAVip Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib ????Transpl Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32629531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32629531 #FOAvip English Wikipedia <ref>{{Cite pmid|32629531}}</ref> Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib #MMPMID32629531 Saraceni F; Scortechini I; Mancini G; Mariani M; Federici I; Gaetani M; Barbatelli P; Minnucci ML; Bagnarelli P; Olivieri A Transpl Infect Dis 2021[Feb]; 23 (1): e13401 PMID32629531show ga Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in severe COVID-19 cases appears to be related to a massive production of pro-inflammatory cytokines. The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID-19; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. We describe a first case of severe COVID-19 developed after hematopoietic stem cell transplantation in a patient with a concomitant chronic GVHD (cGVHD), in which a treatment with ruxolitinib was administered with good tolerance and positive outcome. |COVID-19/*complications/*pathology[MESH] |Graft vs Host Disease/*complications[MESH] |Hematopoietic Stem Cell Transplantation/*adverse effects[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Nitriles[MESH] |Pyrazoles/*therapeutic use[MESH] |Pyrimidines[MESH]Severe COVID-19 in a patient with chronic graft-versus-host disease af(epmc).pdf DeepDyve Pubget Overpricing