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10.1016/j.drudis.2020.06.030 http://scihub22266oqcxt.onion/10.1016/j.drudis.2020.06.030 32629169!7831558!32629169     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2020 ; 25 (10): 1786-1792 Nephropedia Template TP {{tp|p=32629169|t=2020. Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges |pdf=|usr=}}{{32629169}} gab.com Text Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32629169 #FOAvip The Coronavirus Disease 2019 (COVID-19) pandemic is advancing globally, and pharmaceutical prophylaxis is one solution. Here, we propose repositioning chloroquine (CQ) as prophylaxis against COVID-19. CQ blocks viral attachment and entry to host cells and demonstrates efficacy against a variety of viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. Furthermore, CQ is safe, inexpensive, and available. Here, we review the antiviral mechanisms of CQ, its in vitro activity against coronaviruses, its pharmacokinetics (PK) and adverse effects, and why it could be more efficacious as a prophylactic rather than as a therapeutic, given the infection dynamics of SARS-CoV-2. We propose two prophylactic regimens based on efficacy and risk considerations. Although it is largely preclinical data that suggest the potential of CQ, properly planned prophylactic trials and further research are urgently needed. Twit Text FOAVip Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32629169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32629169 #FOAvip English Wikipedia <ref>{{Cite pmid|32629169}}</ref> Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges #MMPMID32629169 Chang R; Sun WZ Drug Discov Today 2020[Oct]; 25 (10): 1786-1792 PMID32629169show ga The Coronavirus Disease 2019 (COVID-19) pandemic is advancing globally, and pharmaceutical prophylaxis is one solution. Here, we propose repositioning chloroquine (CQ) as prophylaxis against COVID-19. CQ blocks viral attachment and entry to host cells and demonstrates efficacy against a variety of viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. Furthermore, CQ is safe, inexpensive, and available. Here, we review the antiviral mechanisms of CQ, its in vitro activity against coronaviruses, its pharmacokinetics (PK) and adverse effects, and why it could be more efficacious as a prophylactic rather than as a therapeutic, given the infection dynamics of SARS-CoV-2. We propose two prophylactic regimens based on efficacy and risk considerations. Although it is largely preclinical data that suggest the potential of CQ, properly planned prophylactic trials and further research are urgently needed. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |Animals[MESH] |Antiviral Agents/*administration & dosage/adverse effects/pharmacokinetics[MESH] |COVID-19/diagnosis/*prevention & control/virology[MESH] |Drug Administration Schedule[MESH] |Humans[MESH] |Hydroxychloroquine/*administration & dosage/adverse effects/pharmacokinetics[MESH] |Patient Safety[MESH] |Risk Assessment[MESH] |Risk Factors[MESH] |SARS-CoV-2/*drug effects/pathogenicity[MESH]Repositioning chloroquine as antiviral prophylaxis against COVID-19: p(epmc).pdf DeepDyve Pubget Overpricing