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10.1016/j.ijantimicag.2020.106078 http://scihub22266oqcxt.onion/10.1016/j.ijantimicag.2020.106078 32629115!7334645!32629115     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32629115&cmd=llinks): Failed to open stream: HTTP request failed! 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A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus?|pdf=|usr=}}{{32629115}} gab.com Text A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus JO: Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=32629115 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is having serious consequences on health and the economy worldwide. All evidence-based treatment strategies need to be considered to combat this new virus. Drugs need to be considered on scientific grounds of efficacy, safety and cost. Chloroquine (CQ) and hydroxychloroquine (HCQ) are old drugs used in the treatment of malaria. Moreover, their antiviral properties have been previously studied, including against coronaviruses, where evidence of efficacy has been found. In the current race against time triggered by the COVID-19 pandemic, the search for new antivirals is very important. However, consideration should be given to old drugs with known anti-coronavirus activity, such as CQ and HCQ. These could be integrated into current treatment strategies while novel treatments are awaited, also in light of the fact that they display an anticoagulant effect that facilitates the activity of low-molecular-weight heparin, aimed at preventing acute respiratory distress syndrome (ARDS)-associated thrombotic events. The safety of CQ and HCQ has been studied for over 50 years, however recently published data raise concerns for cardiac toxicity of CQ/HCQ in patients with COVID-19. This review also re-examines the real information provided by some of the published alarming reports, although concluding that cardiac toxicity should in any case be stringently monitored in patients receiving CQ/HCQ. Twit Text FOAVip A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus ????Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=32629115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32629115 #FOAvip English Wikipedia <ref>{{Cite pmid|32629115}}</ref> A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus? #MMPMID32629115 Oscanoa TJ; Romero-Ortuno R; Carvajal A; Savarino A Int J Antimicrob Agents 2020[Sep]; 56 (3): 106078 PMID32629115show ga The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is having serious consequences on health and the economy worldwide. All evidence-based treatment strategies need to be considered to combat this new virus. Drugs need to be considered on scientific grounds of efficacy, safety and cost. Chloroquine (CQ) and hydroxychloroquine (HCQ) are old drugs used in the treatment of malaria. Moreover, their antiviral properties have been previously studied, including against coronaviruses, where evidence of efficacy has been found. In the current race against time triggered by the COVID-19 pandemic, the search for new antivirals is very important. However, consideration should be given to old drugs with known anti-coronavirus activity, such as CQ and HCQ. These could be integrated into current treatment strategies while novel treatments are awaited, also in light of the fact that they display an anticoagulant effect that facilitates the activity of low-molecular-weight heparin, aimed at preventing acute respiratory distress syndrome (ARDS)-associated thrombotic events. The safety of CQ and HCQ has been studied for over 50 years, however recently published data raise concerns for cardiac toxicity of CQ/HCQ in patients with COVID-19. This review also re-examines the real information provided by some of the published alarming reports, although concluding that cardiac toxicity should in any case be stringently monitored in patients receiving CQ/HCQ. |Angiotensin-Converting Enzyme 2[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Anticoagulants/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Autophagy/drug effects/genetics[MESH] |Betacoronavirus/*drug effects/growth & development/immunology[MESH] |COVID-19[MESH] |Chloroquine/*therapeutic use[MESH] |Coronavirus Infections/*drug therapy/pathology/virology[MESH] |Cytokine Release Syndrome/*prevention & control/virology[MESH] |Cytokines/antagonists & inhibitors/genetics/immunology[MESH] |Disseminated Intravascular Coagulation/*prevention & control/virology[MESH] |Host-Pathogen Interactions/drug effects/genetics/immunology[MESH] |Humans[MESH] |Hydroxychloroquine/*therapeutic use[MESH] |Immunologic Factors/therapeutic use[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/immunology[MESH] |Pneumonia, Viral/*drug therapy/pathology/virology[MESH] |SARS-CoV-2[MESH] |Virus Internalization/drug effects[MESH]A pharmacological perspective of chloroquine in SARS-CoV-2 infection: (epmc).pdf DeepDyve Pubget Overpricing