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10.1155/2020/1594726 http://scihub22266oqcxt.onion/10.1155/2020/1594726 32626733!7315249!32626733     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2020 ; 2020 (ä): 1594726 Nephropedia Template TP {{tp|p=32626733|t=2020. Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice |pdf=|usr=}}{{32626733}} gab.com Text Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32626733 #FOAvip Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds. It has a variety of beneficial properties including anti-inflammatory and antioxidative activities. Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB/c mice. Eight-week-old male BALB/c mice were divided into four groups: control, TQ, cecal ligation and puncture (CLP), and TQ+CLP. CLP was performed after 2 weeks of TQ gavage. After 48 h, we measured the histopathological alterations in the kidney tissue and the serum levels of creatinine (CRE) and blood urea nitrogen (BUN). We also evaluated pyroptosis (NLRP3, caspase-1), apoptosis (caspase-3, caspase-8), proinflammatory (TNF-alpha, IL-1beta, and IL-6)-related protein and gene expression levels. Our results demonstrated that TQ inhibited CLP-induced increased serum CRE and BUN levels. It also significantly inhibited the high levels of NLRP3, caspase-1, caspase-3, caspase-8, TNF-alpha, IL-1beta, and IL-6 induced by CLP. Furthermore, NF-kappaB protein level was significantly decreased in the TQ+CLP group than in the CLP group. Together, our results indicate that TQ may be a potential therapeutic agent for sepsis-induced AKI. Twit Text FOAVip Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=32626733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32626733 #FOAvip English Wikipedia <ref>{{Cite pmid|32626733}}</ref> Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c Mice #MMPMID32626733 Guo LP; Liu SX; Yang Q; Liu HY; Xu LL; Hao YH; Zhang XQ Biomed Res Int 2020[]; 2020 (ä): 1594726 PMID32626733show ga Acute kidney injury (AKI) is a common complication of sepsis and has also been observed in some patients suffering from the new coronavirus pneumonia COVID-19, which is currently a major global concern. Thymoquinone (TQ) is one of the most active ingredients in Nigella sativa seeds. It has a variety of beneficial properties including anti-inflammatory and antioxidative activities. Here, we investigated the possible protective effects of TQ against kidney damage in septic BALB/c mice. Eight-week-old male BALB/c mice were divided into four groups: control, TQ, cecal ligation and puncture (CLP), and TQ+CLP. CLP was performed after 2 weeks of TQ gavage. After 48 h, we measured the histopathological alterations in the kidney tissue and the serum levels of creatinine (CRE) and blood urea nitrogen (BUN). We also evaluated pyroptosis (NLRP3, caspase-1), apoptosis (caspase-3, caspase-8), proinflammatory (TNF-alpha, IL-1beta, and IL-6)-related protein and gene expression levels. Our results demonstrated that TQ inhibited CLP-induced increased serum CRE and BUN levels. It also significantly inhibited the high levels of NLRP3, caspase-1, caspase-3, caspase-8, TNF-alpha, IL-1beta, and IL-6 induced by CLP. Furthermore, NF-kappaB protein level was significantly decreased in the TQ+CLP group than in the CLP group. Together, our results indicate that TQ may be a potential therapeutic agent for sepsis-induced AKI. |Acute Kidney Injury/*drug therapy/*etiology/pathology[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH] |Antioxidants/therapeutic use[MESH] |Apoptosis/drug effects[MESH] |Benzoquinones/*therapeutic use[MESH] |Betacoronavirus[MESH] |Blood Urea Nitrogen[MESH] |COVID-19[MESH] |Coronavirus Infections/complications/drug therapy[MESH] |Creatinine/blood[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Kidney/drug effects/metabolism/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |NF-kappa B/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/drug therapy[MESH] |SARS-CoV-2[MESH]Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BAL(epmc).pdf DeepDyve Pubget Overpricing