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10.1136/bmjresp-2020-000621

http://scihub22266oqcxt.onion/10.1136/bmjresp-2020-000621
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32624494!7337887!32624494
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suck abstract from ncbi


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pmid32624494      BMJ+Open+Respir+Res 2020 ; 7 (1): ä
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  • Improved survival following ward-based non-invasive pressure support for severe hypoxia in a cohort of frail patients with COVID-19: retrospective analysis from a UK teaching hospital #MMPMID32624494
  • Burns GP; Lane ND; Tedd HM; Deutsch E; Douglas F; West SD; Macfarlane JG; Wiscombe S; Funston W
  • BMJ Open Respir Res 2020[Jul]; 7 (1): ä PMID32624494show ga
  • Since the outbreak of COVID-19 in China in December 2019, a pandemic has rapidly developed on a scale that has overwhelmed health services in a number of countries. COVID-19 has the potential to lead to severe hypoxia; this is usually the cause of death if it occurs. In a substantial number of patients, adequate arterial oxygenation cannot be achieved with supplementary oxygen therapy alone. To date, there has been no clear guideline endorsement of ward-based non-invasive pressure support (NIPS) for severely hypoxic patients who are deemed unlikely to benefit from invasive ventilation. We established a ward-based NIPS service for COVID-19 PCR-positive patients, with severe hypoxia, and in whom escalation to critical care for invasive ventilation was not deemed appropriate. A retrospective analysis of survival in these patients was undertaken. Twenty-eight patients were included. Ward-based NIPS for severe hypoxia was associated with a 50% survival in this cohort. This compares favourably with Intensive Care National Audit and Research Centre survival data following invasive ventilation in a less frail, less comorbid and younger population. These results suggest that ward-based NIPS should be considered as a treatment option in an integrated escalation strategy in all units managing respiratory failure secondary to COVID-19.
  • |*Coronavirus Infections/epidemiology/physiopathology/therapy[MESH]
  • |*Frailty/diagnosis/physiopathology/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/epidemiology/physiopathology/therapy[MESH]
  • |*Respiratory Care Units/methods/organization & administration[MESH]
  • |*Respiratory Insufficiency/etiology/mortality/physiopathology/therapy[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Continuous Positive Airway Pressure/*methods[MESH]
  • |Female[MESH]
  • |Geriatric Assessment/*methods[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Outcome and Process Assessment, Health Care[MESH]
  • |Oximetry/methods/statistics & numerical data[MESH]
  • |Oxygen Consumption[MESH]
  • |SARS-CoV-2[MESH]
  • |Survival Analysis[MESH]
  • |Tomography, X-Ray Computed/methods[MESH]


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