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10.1016/j.jaci.2020.05.033 http://scihub22266oqcxt.onion/10.1016/j.jaci.2020.05.033 32624257!7331543!32624257     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2020 ; 146 (2): 285-299 Nephropedia Template TP {{tp|p=32624257|t=2020. Molecular mechanisms and epidemiology of COVID-19 from an allergist s perspective |pdf=|usr=}}{{32624257}} gab.com Text Molecular mechanisms and epidemiology of COVID-19 from an allergist s perspective JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32624257 #FOAvip The global pandemic caused by the newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused worldwide suffering and death of unimaginable magnitude from coronavirus disease 2019 (COVID-19). The virus is transmitted through aerosol droplets, and causes severe acute respiratory syndrome. SARS-CoV-2 uses the receptor-binding domain of its spike protein S1 to attach to the host angiotensin-converting enzyme 2 receptor in lung and airway cells. Binding requires the help of another host protein, transmembrane protease serine S1 member 2. Several factors likely contribute to the efficient transmission of SARS-CoV-2. The receptor-binding domain of SARS-CoV-2 has a 10- to 20-fold higher receptor-binding capacity compared with previous pandemic coronaviruses. In addition, because asymptomatic persons infected with SARS-CoV-2 have high viral loads in their nasal secretions, they can silently and efficiently spread the disease. PCR-based tests have emerged as the criterion standard for the diagnosis of infection. Caution must be exercised in interpreting antibody-based tests because they have not yet been validated, and may give a false sense of security of being "immune" to SARS-CoV-2. We discuss how the development of some symptoms in allergic rhinitis can serve as clues for new-onset COVID-19. There are mixed reports that asthma is a risk factor for severe COVID-19, possibly due to differences in asthma endotypes. The rapid spread of COVID-19 has focused the efforts of scientists on repurposing existing Food and Drug Administration-approved drugs that inhibit viral entry, endocytosis, genome assembly, translation, and replication. Numerous clinical trials have been launched to identify effective treatments for COVID-19. Initial data from a placebo-controlled study suggest faster time to recovery in patients on remdesivir; it is now being evaluated in additional controlled studies. As discussed in this review, till effective vaccines and treatments emerge, it is important to understand the scientific rationale of pandemic-mitigation strategies such as wearing facemasks and social distancing, and implement them. Twit Text FOAVip Molecular mechanisms and epidemiology of COVID-19 from an allergist s perspective ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32624257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32624257 #FOAvip English Wikipedia <ref>{{Cite pmid|32624257}}</ref> Molecular mechanisms and epidemiology of COVID-19 from an allergist s perspective #MMPMID32624257 Hosoki K; Chakraborty A; Sur S J Allergy Clin Immunol 2020[Aug]; 146 (2): 285-299 PMID32624257show ga The global pandemic caused by the newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused worldwide suffering and death of unimaginable magnitude from coronavirus disease 2019 (COVID-19). The virus is transmitted through aerosol droplets, and causes severe acute respiratory syndrome. SARS-CoV-2 uses the receptor-binding domain of its spike protein S1 to attach to the host angiotensin-converting enzyme 2 receptor in lung and airway cells. Binding requires the help of another host protein, transmembrane protease serine S1 member 2. Several factors likely contribute to the efficient transmission of SARS-CoV-2. The receptor-binding domain of SARS-CoV-2 has a 10- to 20-fold higher receptor-binding capacity compared with previous pandemic coronaviruses. In addition, because asymptomatic persons infected with SARS-CoV-2 have high viral loads in their nasal secretions, they can silently and efficiently spread the disease. PCR-based tests have emerged as the criterion standard for the diagnosis of infection. Caution must be exercised in interpreting antibody-based tests because they have not yet been validated, and may give a false sense of security of being "immune" to SARS-CoV-2. We discuss how the development of some symptoms in allergic rhinitis can serve as clues for new-onset COVID-19. There are mixed reports that asthma is a risk factor for severe COVID-19, possibly due to differences in asthma endotypes. The rapid spread of COVID-19 has focused the efforts of scientists on repurposing existing Food and Drug Administration-approved drugs that inhibit viral entry, endocytosis, genome assembly, translation, and replication. Numerous clinical trials have been launched to identify effective treatments for COVID-19. Initial data from a placebo-controlled study suggest faster time to recovery in patients on remdesivir; it is now being evaluated in additional controlled studies. As discussed in this review, till effective vaccines and treatments emerge, it is important to understand the scientific rationale of pandemic-mitigation strategies such as wearing facemasks and social distancing, and implement them. |*Pandemics[MESH] |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH] |Age Factors[MESH] |Alanine/analogs & derivatives/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antiviral Agents/therapeutic use[MESH] |Asthma/*epidemiology/physiopathology[MESH] |Betacoronavirus/drug effects/isolation & purification/*pathogenicity[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Testing[MESH] |COVID-19/diagnosis/*epidemiology/transmission[MESH] |Clinical Laboratory Techniques/methods[MESH] |Clinical Trials as Topic[MESH] |Coronavirus Infections/diagnosis/drug therapy/*epidemiology/transmission[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Masks/supply & distribution[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Physical Distancing[MESH] |Pneumonia, Viral/diagnosis/drug therapy/*epidemiology/transmission[MESH] |Prevalence[MESH] |Quarantine/organization & administration[MESH] |Receptors, Virus/genetics/metabolism[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Molecular mechanisms and epidemiology of COVID-19 from an allergist s (epmc).pdf DeepDyve Pubget Overpricing