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10.1111/iji.12505 http://scihub22266oqcxt.onion/10.1111/iji.12505 32623831!7361549!32623831     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Immunogenet 2020 ; 47 (4): 324-328 Nephropedia Template TP {{tp|p=32623831|t=2020. A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients |pdf=|usr=}}{{32623831}} gab.com Text A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients JO: Int J Immunogenet http://www.kidney.de/pget.php?&tw=1&pmid=32623831 #FOAvip We analysed data from 80 patients who tested positive for SARS-CoV-2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA- DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94-3.22) and infection. A bias towards an increased representation of HLA-A*26, HLA-DRB1*15, HLA-DRB1*10 and DRB1*11 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. Likewise, HLA-A*02, HLA-B*44 and HLA-C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. This is relevant information for the clinical management of patients in the setting of the current SARS-CoV-2 pandemic and potentially in risk-assessing staff interactions with infected patients. Twit Text FOAVip A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients ????Int J Immunogenet http://www.kidney.de/pget.php?&tw=1&pmid=32623831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32623831 #FOAvip English Wikipedia <ref>{{Cite pmid|32623831}}</ref> A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients #MMPMID32623831 Poulton K; Wright P; Hughes P; Savic S; Welberry Smith M; Guiver M; Morton M; van Dellen D; Tholouli E; Wynn R; Clark B Int J Immunogenet 2020[Aug]; 47 (4): 324-328 PMID32623831show ga We analysed data from 80 patients who tested positive for SARS-CoV-2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA- DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94-3.22) and infection. A bias towards an increased representation of HLA-A*26, HLA-DRB1*15, HLA-DRB1*10 and DRB1*11 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. Likewise, HLA-A*02, HLA-B*44 and HLA-C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. This is relevant information for the clinical management of patients in the setting of the current SARS-CoV-2 pandemic and potentially in risk-assessing staff interactions with infected patients. |*Histocompatibility Testing[MESH] |Alleles[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/pathology[MESH] |Gene Frequency[MESH] |Genetic Predisposition to Disease/*genetics[MESH] |HLA-A Antigens/genetics[MESH] |HLA-B Antigens/genetics[MESH] |HLA-C Antigens/genetics[MESH] |HLA-DQ beta-Chains/genetics[MESH] |HLA-DRB1 Chains/genetics[MESH] |Humans[MESH] |Organ Transplantation[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/pathology[MESH] |SARS-CoV-2[MESH]A role for human leucocyte antigens in the susceptibility to SARS-Cov-(epmc).pdf DeepDyve Pubget Overpricing