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10.1007/s10571-020-00915-1

http://scihub22266oqcxt.onion/10.1007/s10571-020-00915-1
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32623546!7334623!32623546
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suck abstract from ncbi


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pmid32623546      Cell+Mol+Neurobiol 2022 ; 42 (1): 305-309
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  • Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus #MMPMID32623546
  • Xu J; Lazartigues E
  • Cell Mol Neurobiol 2022[Jan]; 42 (1): 305-309 PMID32623546show ga
  • The recent outbreak of 2019 coronavirus disease (COVID-19), caused by a novel coronavirus, has now spread quickly worldwide. Like the severe acute respiratory syndrome coronavirus (SARS-CoV), this novel type of coronavirus, SARS-CoV-2, has been demonstrated to utilize angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. There is a growing body of reports indicating that COVID-19 patients, especially those in severe condition, exhibit neurological symptoms, thus supporting the possibility that SARS-CoV-2 could infect and damage neurons within the central nervous system in humans. Using human pluripotent stem cells-derived neurons, here we show the expression of ACE2 in human neurons via immunocytochemistry. From this perspective, we elaborate on the idea that the neuro-invasive potential of SARS-CoV-2 should be considered as a possible contributory factor, as well as a therapeutic target, for the severe respiratory symptoms in critical COVID-19 cases.
  • |Angiotensin-Converting Enzyme 2/*metabolism[MESH]
  • |COVID-19/*enzymology/*virology[MESH]
  • |Humans[MESH]
  • |Models, Biological[MESH]
  • |Neurons/*enzymology/*pathology[MESH]
  • |Organ Specificity[MESH]
  • |Pluripotent Stem Cells/metabolism[MESH]


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