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10.1007/s00330-020-07033-y http://scihub22266oqcxt.onion/10.1007/s00330-020-07033-y 32623505!7334627!32623505     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Radiol 2020 ; 30 (12): 6808-6817 Nephropedia Template TP {{tp|p=32623505|t=2020. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis |pdf=|usr=}}{{32623505}} gab.com Text Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis JO: Eur Radiol http://www.kidney.de/pget.php?&tw=1&pmid=32623505 #FOAvip OBJECTIVES: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients' outcome. METHODS: From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, < 5%; 2:5-25%; 3:26-50%; 4:51-75%; 5, > 75%; range 0-5; global score 0-25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients' outcome. RESULTS: Ground glass opacities were predominant in early-phase (</= 7 days since symptoms' onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7 days). CT score was significantly higher in critical and severe than in mild stage (p < 0.0001), and among late-phase than early-phase patients (p < 0.0001). CT score was significantly correlated with CRP (p < 0.0001, r = 0.6204) and D-dimer (p < 0.0001, r = 0.6625) levels. A CT score of >/= 18 was associated with an increased mortality risk and was found to be predictive of death both in univariate (HR, 8.33; 95% CI, 3.19-21.73; p < 0.0001) and multivariate analysis (HR, 3.74; 95% CI, 1.10-12.77; p = 0.0348). CONCLUSIONS: Our preliminary data suggest the potential role of CT score for predicting the outcome of SARS-CoV-2 patients. CT score is highly correlated with laboratory findings and disease severity and might be beneficial to speed-up diagnostic workflow in symptomatic cases. KEY POINTS: * CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. * A CT score >/= 18 has shown to be highly predictive of patient's mortality in short-term follow-up. * Our multivariate analysis demonstrated that CT parenchymal assessment may more accurately reflect short-term outcome, providing a direct visualization of anatomic injury compared with non-specific inflammatory biomarkers. Twit Text FOAVip Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis ????Eur Radiol http://www.kidney.de/pget.php?&tw=1&pmid=32623505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32623505 #FOAvip English Wikipedia <ref>{{Cite pmid|32623505}}</ref> Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis #MMPMID32623505 Francone M; Iafrate F; Masci GM; Coco S; Cilia F; Manganaro L; Panebianco V; Andreoli C; Colaiacomo MC; Zingaropoli MA; Ciardi MR; Mastroianni CM; Pugliese F; Alessandri F; Turriziani O; Ricci P; Catalano C Eur Radiol 2020[Dec]; 30 (12): 6808-6817 PMID32623505show ga OBJECTIVES: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients' outcome. METHODS: From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, < 5%; 2:5-25%; 3:26-50%; 4:51-75%; 5, > 75%; range 0-5; global score 0-25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients' outcome. RESULTS: Ground glass opacities were predominant in early-phase ( 7 days). CT score was significantly higher in critical and severe than in mild stage (p < 0.0001), and among late-phase than early-phase patients (p < 0.0001). CT score was significantly correlated with CRP (p < 0.0001, r = 0.6204) and D-dimer (p < 0.0001, r = 0.6625) levels. A CT score of >/= 18 was associated with an increased mortality risk and was found to be predictive of death both in univariate (HR, 8.33; 95% CI, 3.19-21.73; p < 0.0001) and multivariate analysis (HR, 3.74; 95% CI, 1.10-12.77; p = 0.0348). CONCLUSIONS: Our preliminary data suggest the potential role of CT score for predicting the outcome of SARS-CoV-2 patients. CT score is highly correlated with laboratory findings and disease severity and might be beneficial to speed-up diagnostic workflow in symptomatic cases. KEY POINTS: * CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. * A CT score >/= 18 has shown to be highly predictive of patient's mortality in short-term follow-up. * Our multivariate analysis demonstrated that CT parenchymal assessment may more accurately reflect short-term outcome, providing a direct visualization of anatomic injury compared with non-specific inflammatory biomarkers. |*Betacoronavirus[MESH] |*Pandemics[MESH] |Adult[MESH] |COVID-19[MESH] |Coronavirus Infections/*diagnosis/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Lung/*diagnostic imaging[MESH] |Male[MESH] |Middle Aged[MESH] |Pneumonia, Viral/*diagnosis/epidemiology[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Chest CT score in COVID-19 patients: correlation with disease severity(epmc).pdf DeepDyve Pubget Overpricing