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10.1016/j.jclinepi.2020.06.037 http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2020.06.037 32622902!7332449!32622902     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Epidemiol 2020 ; 126 (ä): 172-176 Nephropedia Template TP {{tp|p=32622902|t=2020. Testing COVID-19 tests faces methodological challenges |pdf=|usr=}}{{32622902}} gab.com Text Testing COVID-19 tests faces methodological challenges JO: J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32622902 #FOAvip In battling the COVID-19 pandemic, testing is essential. The detection of viral RNA allows the identification of infected persons, whereas the detection of antibodies may reveal a response to a previous infection. Tests for coronavirus should be rigorously evaluated in terms of their analytical and clinical performance. This poses not only logistic challenges, but also methodological ones. Some of these are generic for the diagnostic accuracy paradigm, whereas others are more specific for tests for viruses. Problematic for evaluations of the clinical performance of tests for viral RNA is the absence of an independent reference standard. Many studies lack rigor in terms of the recruitment of study participants. Study reports are often insufficiently informative, which makes it difficult to assess the applicability of study findings. Attempts to summarize the performance of these tests in terms of a single estimate of the clinical sensitivity fail to do justice to the identifiable sources of the large heterogeneity in mechanisms for generating false negative results. Twit Text FOAVip Testing COVID-19 tests faces methodological challenges ????J Clin Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=32622902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32622902 #FOAvip English Wikipedia <ref>{{Cite pmid|32622902}}</ref> Testing COVID-19 tests faces methodological challenges #MMPMID32622902 Bossuyt PM J Clin Epidemiol 2020[Oct]; 126 (ä): 172-176 PMID32622902show ga In battling the COVID-19 pandemic, testing is essential. The detection of viral RNA allows the identification of infected persons, whereas the detection of antibodies may reveal a response to a previous infection. Tests for coronavirus should be rigorously evaluated in terms of their analytical and clinical performance. This poses not only logistic challenges, but also methodological ones. Some of these are generic for the diagnostic accuracy paradigm, whereas others are more specific for tests for viruses. Problematic for evaluations of the clinical performance of tests for viral RNA is the absence of an independent reference standard. Many studies lack rigor in terms of the recruitment of study participants. Study reports are often insufficiently informative, which makes it difficult to assess the applicability of study findings. Attempts to summarize the performance of these tests in terms of a single estimate of the clinical sensitivity fail to do justice to the identifiable sources of the large heterogeneity in mechanisms for generating false negative results. |*Betacoronavirus[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques/*methods/*standards[MESH] |Coronavirus Infections/*diagnosis[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnosis[MESH] |Reproducibility of Results[MESH]Testing COVID-19 tests faces methodological challenges (epmc).pdf DeepDyve Pubget Overpricing