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10.1016/j.jaut.2020.102510 http://scihub22266oqcxt.onion/10.1016/j.jaut.2020.102510 32622513!7327470!32622513     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2020 ; 113 (ä): 102510 Nephropedia Template TP {{tp|p=32622513|t=2020. The roles of PPARgamma and its agonists in autoimmune diseases: A comprehensive review |pdf=|usr=}}{{32622513}} gab.com Text The roles of PPARgamma and its agonists in autoimmune diseases: A comprehensive review JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=32622513 #FOAvip Autoimmune diseases are common diseases of the immune system that are characterized by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune tolerance and the prolonged inflammatory reaction are undisputedly core steps in the initiation and maintenance of autoimmunity. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that belong to the nuclear hormone receptor family and act as ligand-activated transcription factors. There are three different isotypes of PPARs: PPARalpha, PPARgamma, and PPARbeta/delta. PPARgamma is an established regulator of glucose homeostasis and lipid metabolism. Recent studies have demonstrated that PPARgamma exhibits anti-inflammatory and anti-fibrotic effects in multiple disease models. PPARgamma can also modulate the activation and polarization of macrophages, regulate the function of dendritic cells and mediate T cell survival, activation, and differentiation. In this review, we summarize the signaling pathways and biological functions of PPARgamma and focus on how PPARgamma and its agonists play protective roles in autoimmune diseases, including autoimmune thyroid diseases, multiple sclerosis, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, primary Sjogren syndrome and primary biliary cirrhosis. Twit Text FOAVip The roles of PPARgamma and its agonists in autoimmune diseases: A comprehensive review ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=32622513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32622513 #FOAvip English Wikipedia <ref>{{Cite pmid|32622513}}</ref> The roles of PPARgamma and its agonists in autoimmune diseases: A comprehensive review #MMPMID32622513 Liu Y; Wang J; Luo S; Zhan Y; Lu Q J Autoimmun 2020[Sep]; 113 (ä): 102510 PMID32622513show ga Autoimmune diseases are common diseases of the immune system that are characterized by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune tolerance and the prolonged inflammatory reaction are undisputedly core steps in the initiation and maintenance of autoimmunity. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that belong to the nuclear hormone receptor family and act as ligand-activated transcription factors. There are three different isotypes of PPARs: PPARalpha, PPARgamma, and PPARbeta/delta. PPARgamma is an established regulator of glucose homeostasis and lipid metabolism. Recent studies have demonstrated that PPARgamma exhibits anti-inflammatory and anti-fibrotic effects in multiple disease models. PPARgamma can also modulate the activation and polarization of macrophages, regulate the function of dendritic cells and mediate T cell survival, activation, and differentiation. In this review, we summarize the signaling pathways and biological functions of PPARgamma and focus on how PPARgamma and its agonists play protective roles in autoimmune diseases, including autoimmune thyroid diseases, multiple sclerosis, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, primary Sjogren syndrome and primary biliary cirrhosis. |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology/therapeutic use[MESH] |Autoimmune Diseases/drug therapy/*immunology[MESH] |Disease Models, Animal[MESH] |Glucose/metabolism[MESH] |Humans[MESH] |Lipid Metabolism/drug effects/immunology[MESH] |PPAR gamma/agonists/*metabolism[MESH]The roles of PPARgamma and its agonists in autoimmune diseases: A comp(epmc).pdf DeepDyve Pubget Overpricing