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10.1016/j.mayocp.2020.05.006

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2020.05.006
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32622449!7236707!32622449
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suck abstract from ncbi


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pmid32622449      Mayo+Clin+Proc 2020 ; 95 (7): 1445-1453
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  • Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide #MMPMID32622449
  • Sanchis-Gomar F; Lavie CJ; Mehra MR; Henry BM; Lippi G
  • Mayo Clin Proc 2020[Jul]; 95 (7): 1445-1453 PMID32622449show ga
  • Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and higher mortality. Clinicians need to be more aggressive when treating obese, especially severely obese, patients with COVID-19 infection.
  • |*Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology/therapy[MESH]
  • |Humans[MESH]
  • |Obesity/*complications[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*epidemiology/therapy[MESH]
  • |Prognosis[MESH]


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