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10.1016/j.msard.2020.102341

http://scihub22266oqcxt.onion/10.1016/j.msard.2020.102341
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32622338!7318946!32622338
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suck abstract from ncbi


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pmid32622338      Mult+Scler+Relat+Disord 2020 ; 44 (ä): 102341
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  • Negative SARS-CoV-2 antibody testing following COVID-19 infection in Two MS patients treated with ocrelizumab #MMPMID32622338
  • Thornton JR; Harel A
  • Mult Scler Relat Disord 2020[Sep]; 44 (ä): 102341 PMID32622338show ga
  • BACKGROUND: It is unknown whether MS disease modifying therapies impact ability to mount an antibody response to SARS-CoV-2. METHODS: Case series and literature review. We report a series of two MS patients who developed COVID-19 while on Ocrelizumab therapy and subsequently exhibited negative SARS-CoV-2 serology. RESULTS: A 42-year-old man and 39-year-old woman with MS developed COVID-19 while on Ocrelizumab therapy. Neither patient required hospitalization. The man exhibited negative serology at 7- and 9-weeks post-infection. The woman exhibited negative serology at 6- and 12-weeks post-infection. CONCLUSIONS: Large studies are essential to determine whether certain DMTs may blunt SARS-CoV-2 antibody production.
  • |*COVID-19 Serological Testing[MESH]
  • |Adult[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |COVID-19/complications/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*therapeutic use[MESH]
  • |Male[MESH]


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