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10.1016/j.addr.2020.06.026 http://scihub22266oqcxt.onion/10.1016/j.addr.2020.06.026 32622021!7329694!32622021     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2020 ; 159 (ä): 344-363 Nephropedia Template TP {{tp|p=32622021|t=2020. Lipid nanoparticle technology for therapeutic gene regulation in the liver |pdf=|usr=}}{{32622021}} gab.com Text Lipid nanoparticle technology for therapeutic gene regulation in the liver JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32622021 #FOAvip Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease symptoms. Targeting the root cause of diseases originating in the liver by regulating malfunctioning genes with nucleic acid-based drugs holds great promise as a therapeutic approach. However, employing nucleic acid therapeutics in vivo is challenging due to their unfavorable characteristics. Lipid nanoparticle (LNP) delivery technology is a revolutionary development that has enabled clinical translation of gene therapies. LNPs can deliver siRNA, mRNA, DNA, or gene-editing complexes, providing opportunities to treat hepatic diseases by silencing pathogenic genes, expressing therapeutic proteins, or correcting genetic defects. Here we discuss the state-of-the-art LNP technology for hepatic gene therapy including formulation design parameters, production methods, preclinical development and clinical translation. Twit Text FOAVip Lipid nanoparticle technology for therapeutic gene regulation in the liver ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32622021 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32622021 #FOAvip English Wikipedia <ref>{{Cite pmid|32622021}}</ref> Lipid nanoparticle technology for therapeutic gene regulation in the liver #MMPMID32622021 Witzigmann D; Kulkarni JA; Leung J; Chen S; Cullis PR; van der Meel R Adv Drug Deliv Rev 2020[]; 159 (ä): 344-363 PMID32622021show ga Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease symptoms. Targeting the root cause of diseases originating in the liver by regulating malfunctioning genes with nucleic acid-based drugs holds great promise as a therapeutic approach. However, employing nucleic acid therapeutics in vivo is challenging due to their unfavorable characteristics. Lipid nanoparticle (LNP) delivery technology is a revolutionary development that has enabled clinical translation of gene therapies. LNPs can deliver siRNA, mRNA, DNA, or gene-editing complexes, providing opportunities to treat hepatic diseases by silencing pathogenic genes, expressing therapeutic proteins, or correcting genetic defects. Here we discuss the state-of-the-art LNP technology for hepatic gene therapy including formulation design parameters, production methods, preclinical development and clinical translation. |*Gene Expression Regulation[MESH] |*Gene Transfer Techniques[MESH] |*Genetic Therapy[MESH] |Animals[MESH] |Humans[MESH] |Lipids/*administration & dosage[MESH] |Liver/*metabolism[MESH] |Nanoparticles/*administration & dosage[MESH]Lipid nanoparticle technology for therapeutic gene regulation in the l(epmc).pdf DeepDyve Pubget Overpricing