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10.1016/j.hrthm.2020.06.033

http://scihub22266oqcxt.onion/10.1016/j.hrthm.2020.06.033
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32621881!7328618!32621881
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suck abstract from ncbi


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pmid32621881      Heart+Rhythm 2020 ; 17 (11): 1960-1966
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  • Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval #MMPMID32621881
  • Samuel S; Friedman RA; Sharma C; Ganigara M; Mitchell E; Schleien C; Blaufox AD
  • Heart Rhythm 2020[Nov]; 17 (11): 1960-1966 PMID32621881show ga
  • BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN). OBJECTIVES: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. METHODS: A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. RESULTS: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 +/- 19 ms vs 425 +/- 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 +/- 15 ms vs 425 +/- 15 ms, P = 1). CONCLUSIONS: In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients.
  • |*Arrhythmias, Cardiac/diagnosis/epidemiology[MESH]
  • |*Azithromycin/administration & dosage/adverse effects[MESH]
  • |*Coronavirus Infections/diagnosis/drug therapy/epidemiology/physiopathology[MESH]
  • |*Electrocardiography/methods/statistics & numerical data[MESH]
  • |*Hydroxychloroquine/administration & dosage/adverse effects[MESH]
  • |*Long QT Syndrome/chemically induced/diagnosis[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/drug therapy/epidemiology/physiopathology[MESH]
  • |Anti-Infective Agents/administration & dosage/adverse effects[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |Clinical Laboratory Techniques/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |New York City/epidemiology[MESH]
  • |Outcome and Process Assessment, Health Care[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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