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10.1016/j.virusres.2020.198082 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198082 32621841!7328648!32621841     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Res 2020 ; 288 (ä): 198082 Nephropedia Template TP {{tp|p=32621841|t=2020. Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 |pdf=|usr=}}{{32621841}} gab.com Text Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32621841 #FOAvip The outbreak of the 2019 novel coronavirus (SARS-CoV-2) has infected millions of people with a large number of deaths across the globe. The existing therapies are limited in dealing with SARS-CoV-2 due to the sudden appearance of the virus. Therefore, vaccines and antiviral medicines are in desperate need. We took immune-informatics approaches to identify B- and T-cell epitopes for surface glycoprotein (S), membrane glycoprotein (M) and nucleocapsid protein (N) of SARS-CoV-2, followed by estimating their antigenicity and interactions with the human leukocyte antigen (HLA) alleles. Allergenicity, toxicity, physiochemical properties analysis and stability were examined to confirm the specificity and selectivity of the epitope candidates. We identified a total of five B cell epitopes in RBD of S protein, seven MHC class-I, and 18 MHC class-II binding T-cell epitopes from S, M and N protein which showed non-allergenic, non-toxic and highly antigenic features and non-mutated in 55,179 SARS-CoV-2 virus strains until June 25, 2020. The epitopes identified here can be a potentially good candidate repertoire for vaccine development. Twit Text FOAVip Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32621841 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32621841 #FOAvip English Wikipedia <ref>{{Cite pmid|32621841}}</ref> Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2 #MMPMID32621841 Lin L; Ting S; Yufei H; Wendong L; Yubo F; Jing Z Virus Res 2020[Oct]; 288 (ä): 198082 PMID32621841show ga The outbreak of the 2019 novel coronavirus (SARS-CoV-2) has infected millions of people with a large number of deaths across the globe. The existing therapies are limited in dealing with SARS-CoV-2 due to the sudden appearance of the virus. Therefore, vaccines and antiviral medicines are in desperate need. We took immune-informatics approaches to identify B- and T-cell epitopes for surface glycoprotein (S), membrane glycoprotein (M) and nucleocapsid protein (N) of SARS-CoV-2, followed by estimating their antigenicity and interactions with the human leukocyte antigen (HLA) alleles. Allergenicity, toxicity, physiochemical properties analysis and stability were examined to confirm the specificity and selectivity of the epitope candidates. We identified a total of five B cell epitopes in RBD of S protein, seven MHC class-I, and 18 MHC class-II binding T-cell epitopes from S, M and N protein which showed non-allergenic, non-toxic and highly antigenic features and non-mutated in 55,179 SARS-CoV-2 virus strains until June 25, 2020. The epitopes identified here can be a potentially good candidate repertoire for vaccine development. |Amino Acid Sequence[MESH] |Betacoronavirus/drug effects/*immunology[MESH] |Binding Sites[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/prevention & control/virology[MESH] |Coronavirus M Proteins[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Epitopes, B-Lymphocyte/*chemistry/immunology/metabolism[MESH] |Epitopes, T-Lymphocyte/*chemistry/immunology/metabolism[MESH] |Humans[MESH] |Immunogenicity, Vaccine[MESH] |Models, Molecular[MESH] |Nucleocapsid Proteins/*chemistry/immunology/metabolism[MESH] |Pandemics/prevention & control[MESH] |Phosphoproteins[MESH] |Pneumonia, Viral/immunology/prevention & control/virology[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/immunology/metabolism[MESH] |Viral Matrix Proteins/*chemistry/immunology/metabolism[MESH]Epitope-based peptide vaccines predicted against novel coronavirus dis(epmc).pdf DeepDyve Pubget Overpricing