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10.1002/jmv.26260

http://scihub22266oqcxt.onion/10.1002/jmv.26260
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32621621!7361199!32621621
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suck abstract from ncbi


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pmid32621621      J+Med+Virol 2021 ; 93 (1): 472-480
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  • Lopinavir/ritonavir is associated with pneumonia resolution in COVID-19 patients with influenza coinfection: A retrospective matched-pair cohort study #MMPMID32621621
  • Yu C; Zhang Z; Guo Y; Shi J; Pei G; Yao Y; Liao W; Zeng R
  • J Med Virol 2021[Jan]; 93 (1): 472-480 PMID32621621show ga
  • During the early stages of the pandemic, some coronavirus disease (COVID-19) patients were misdiagnosed as having influenza, which aroused the concern that some deaths attributed to influenza were actually COVID-19-related. However, little is known about whether coinfection with influenza contributes to severity of COVID-19 pneumonia, and the optimal therapeutic strategy for these patients. We retrospectively studied 128 hospitalized patients with COVID-19 pneumonia. All patients were positive severe acute respiratory syndrome coronavirus 2 positive by nucleic acid detection. Sixty-four cases were coinfected with influenza A/B and the other 64 were influenza negative, matched by age, sex, and days from onset of symptoms. Among the 64 coinfected patients, 54 (84.4%) were coinfected with influenza A, and 10 (15.6%) with influenza B. The median duration of viral shedding time from admission was longer for patients with influenza coinfection (17.0 days) than for those without influenza coinfection (12.0 days) (P < .001). The multivariable Cox proportional hazards model showed that the hazards ratio of resolution in lung involvement was 1.878 (P = .020) for patients administered lopinavir/ritonavir, compared with those not administered lopinavir/ritonavir (95% confidence interval: 1.103-3.196). Among influenza coinfected patients, those treated with lopinavir/ritonavir exhibited faster pneumonia resolution within 2 weeks after symptom onset (37% vs 1%; P = .001). There was no difference in lung involvement between influenza coinfected and noninfected groups. Lopinavir/ritonavir eliminated the difference of lung involvement between influenza coinfected and noninfected groups, indicating that lopinavir/ritonavir is associated with pneumonia resolution in COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Cohort Studies[MESH]
  • |Coinfection/*drug therapy[MESH]
  • |Drug Therapy, Combination/methods[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Influenza, Human/*drug therapy/virology[MESH]
  • |Lopinavir/*therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia/*drug therapy/virology[MESH]
  • |Retrospective Studies[MESH]
  • |Ritonavir/*therapeutic use[MESH]
  • |SARS-CoV-2/drug effects[MESH]


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