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10.1007/s11684-020-0800-y

http://scihub22266oqcxt.onion/10.1007/s11684-020-0800-y
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32621202!7333369!32621202
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suck abstract from ncbi


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pmid32621202      Front+Med 2020 ; 14 (5): 601-612
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  • Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis #MMPMID32621202
  • Xu J; Huang C; Fan G; Liu Z; Shang L; Zhou F; Wang Y; Yu J; Yang L; Xie K; Huang Z; Huang L; Gu X; Li H; Zhang Y; Wang Y; Hayden FG; Horby PW; Cao B; Wang C
  • Front Med 2020[Oct]; 14 (5): 601-612 PMID32621202show ga
  • The possible effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on COVID-19 disease severity have generated considerable debate. We performed a single-center, retrospective analysis of hospitalized adult COVID-19 patients in Wuhan, China, who had definite clinical outcome (dead or discharged) by February 15, 2020. Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes. The medical records from 702 patients were screened. Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication, 40 patients were receiving ACEI/ARB as part of their regimen, and 61 patients were on antihypertensive medication other than ACEI/ARB. We observed no statistically significant differences in percentages of in-hospital mortality (28% vs. 34%, P = 0.46), ICU admission (20% vs. 28%, P = 0.37) or invasive mechanical ventilation (18% vs. 26%, P = 0.31) between patients with or without ACEI/ARB treatment. Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes. Our findings confirm the lack of an association between chronic receipt of renin-angiotensin system antagonists and severe outcomes of COVID-19. Patients should continue previous anti-hypertensive therapy until further evidence is available.
  • |*Betacoronavirus/drug effects/physiology[MESH]
  • |*Coronavirus Infections/mortality/physiopathology/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/mortality/physiopathology/therapy[MESH]
  • |Angiotensin Receptor Antagonists/*therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH]
  • |Antihypertensive Agents/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Hypertension/*drug therapy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Outcome and Process Assessment, Health Care[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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